Artificially sweetened versus regular mixers increase gastric emptying and alcohol absorption

Simple item page
dc.contributor.authorWu, K.
dc.contributor.authorChaikomin, R.
dc.contributor.authorDoran, S.
dc.contributor.authorJones, K.
dc.contributor.authorHorowitz, M.
dc.contributor.authorRayner, C.
dc.date.issued2006
dc.description.abstract<h4>Background</h4>Mixed alcoholic drinks are increasingly being consumed in "diet" varieties, which could potentially empty more rapidly from the stomach and thereby increase the rate of alcohol absorption when compared with "regular" versions containing sugar.<h4>Methods</h4>We studied 8 healthy males twice in randomized order. On each day, they consumed an orange-flavored vodka beverage (30 g ethanol in 600 mL), made with either "regular" mixer containing sucrose (total 478 kcal), or "diet" mixer (225 kcal).<h4>Results</h4>Gastric half-emptying time measured by ultrasound (mean+/-standard deviation) was less for the "diet" than the "regular" drink (21.1+/-9.5 vs 36.3+/-15.3 minutes, P <.01). Both the peak blood ethanol concentration (0.053+/-0.006 vs 0.034+/-0.008 g%, P <.001) and the area under the blood ethanol concentration curve between 0 and 180 minutes (5.2+/-0.7 vs 3.2+/-0.7 units, P <.001) were greater with the "diet" drink.<h4>Conclusions</h4>Substitution of artificial sweeteners for sucrose in mixed alcoholic beverages may have a marked effect on the rate of gastric emptying and the blood alcohol response.
dc.description.statementofresponsibilityKeng-Liang Wu, Reawika Chaikomin, Selena Doran, Karen L. Jones, Michael Horowitz and Christopher K. Rayner
dc.identifier.citationAmerican Journal of Medicine, 2006; 119(9):802-804
dc.identifier.doi10.1016/j.amjmed.2006.02.005
dc.identifier.issn0002-9343
dc.identifier.issn1555-7162
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.urihttp://hdl.handle.net/2440/23438
dc.language.isoen
dc.publisherExcerpta Medica Inc
dc.rightsCopyright © 2006 Elsevier
dc.source.urihttps://doi.org/10.1016/j.amjmed.2006.02.005
dc.subjectHumans
dc.subjectEthanol
dc.subjectSucrose
dc.subjectSweetening Agents
dc.subjectCross-Over Studies
dc.subjectDouble-Blind Method
dc.subjectAbsorption
dc.subjectGastric Emptying
dc.subjectBeverages
dc.subjectAdult
dc.subjectMale
dc.titleArtificially sweetened versus regular mixers increase gastric emptying and alcohol absorption
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications