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Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

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dc.contributor.authorMorrison, J.
dc.contributor.authorBotting, K.
dc.contributor.authorDarby, J.
dc.contributor.authorDavid, A.
dc.contributor.authorDyson, R.
dc.contributor.authorGatford, K.
dc.contributor.authorGray, C.
dc.contributor.authorHerrera, E.
dc.contributor.authorHirst, J.
dc.contributor.authorKim, B.
dc.contributor.authorKind, K.
dc.contributor.authorKrause, B.
dc.contributor.authorMatthews, S.
dc.contributor.authorPalliser, H.
dc.contributor.authorRegnault, T.
dc.contributor.authorRichardson, B.
dc.contributor.authorSasaki, A.
dc.contributor.authorThompson, L.
dc.contributor.authorBerry, M.
dc.date.issued2018
dc.description.abstractOver 30 years ago Sir David Barker first proposed the theory that events in early life could explain an individuals' risk of non-communicable disease in later life; the Developmental Origins of Health and Disease (DOHaD) theory. During the 1990s the validity of the DOHaD theory was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, their strengths and limitations as an experimental model of DOHaD and their potential to enhance clinical therapeutic innovation to improve human health.
dc.description.statementofresponsibilityJanna L. Morrison, Kimberley J. Botting, Jack R.T. Darby, Anna L. David, Rebecca M. Dyson, Kathryn L. Gatford, Clint Gray, Emilio A. Herrera, Jonathan J. Hirst, Bona Kim, Karen L. Kind, Bernardo J. Krause, Stephen G. Matthews, Hannah K. Palliser, Timothy R.H. Regnault, Bryan S. Richardson, Aya Sasaki, Loren P. Thompson and Mary J. Berry
dc.identifier.citationJournal of Physiology, 2018; 596(23):5535-5569
dc.identifier.doi10.1113/jp274948
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.orcidGatford, K. [0000-0002-2823-3004]
dc.identifier.urihttp://hdl.handle.net/2440/117530
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1066916
dc.rights© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society
dc.source.urihttps://doi.org/10.1113/JP274948
dc.subjectDOHaD; guinea pig; animal models; fetus; placenta; pregnancy
dc.titleGuinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic
dc.typeJournal article
pubs.publication-statusPublished

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