The Effects of COVID-19 on the Placenta During Pregnancy
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Date
2021
Authors
Rad, H.S.
Röhl, J.
Stylianou, N.
Allenby, M.C.
Bazaz, S.R.
Warkiani, M.E.
Guimaraes, F.S.F.
Clifton, V.L.
Kulasinghe, A.
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Frontiers in Immunology, 2021; 12:743022-1-743022-11
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Habib Sadeghi Rad, Joan Röhl, Nataly Stylianou, Mark C. Allenby, Sajad Razavi Bazaz, Majid E. Warkiani, Fernando S. F. Guimaraes, Vicki L. Clifton, and Arutha Kulasinghe
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Abstract
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.
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Copyright © 2021 Rad, Röhl, Stylianou, Allenby, Bazaz, Warkiani, Guimaraes, Clifton and Kulasinghe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.