Neurotropic viruses and cerebral palsy: population based case-control study

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dc.contributor.authorGibson, C.
dc.contributor.authorMacLennan, A.
dc.contributor.authorGoldwater, P.
dc.contributor.authorHaan, E.
dc.contributor.authorPriest, K.
dc.contributor.authorDekker, G.
dc.date.issued2006
dc.description.abstractObjective: To investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses. Design: Population based case-control study. Setting: Adelaide Women's and Children's Hospital Research Laboratory. Participants and main outcome measures: Newborn screening cards of 443 white case patients with cerebral palsy and 883 white controls were tested for viral nucleic acids from enteroviruses and herpes viruses by using polymerase chain reaction. Herpes group A viruses included herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 8 (HHV-8), and herpes group B viruses included varicella zoster virus (VZV) and human herpes viruses 6 and 7 (HHV-6 and HHV-7). Results: The prevalence of viral nucleic acids in the control population was high: 39.8% of controls tested positive, and the prevalence was highest in preterm babies. The detection of herpes group B viral nucleic acids increased the risk of developing cerebral palsy (odds ratio 1.68, 95% confidence interval 1.09 to 2.59). Conclusions: Perinatal exposure to neurotropic viruses is associated with preterm delivery and cerebral palsy.
dc.description.statementofresponsibilityCatherine S. Gibson, Alastair H. MacLennan, Paul N. Goldwater, Eric A. Haan, Kevin Priest and Gustaaf A. Dekker.
dc.identifier.citationThe BMJ, 2006; 332(7533):76-79
dc.identifier.doi10.1136/bmj.38668.616806.3A
dc.identifier.issn0959-535X
dc.identifier.issn1756-1833
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.urihttp://hdl.handle.net/2440/35724
dc.language.isoen
dc.publisherBritish Med Journal Publ Group
dc.rights© 2006 BMJ Publishing Group
dc.source.urihttps://doi.org/10.1136/bmj.38668.616806.3a
dc.subjectSouth Australian Cerebral Palsy Research Group
dc.subjectHumans
dc.subjectHerpesviridae
dc.subjectPregnancy Complications, Infectious
dc.subjectHerpesviridae Infections
dc.subjectCerebral Palsy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectOdds Ratio
dc.subjectCase-Control Studies
dc.subjectPregnancy
dc.subjectInfant, Newborn
dc.subjectFemale
dc.subjectObstetric Labor, Premature
dc.titleNeurotropic viruses and cerebral palsy: population based case-control study
dc.typeJournal article
pubs.publication-statusPublished

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