Time course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation

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dc.contributor.authorLim, H.
dc.contributor.authorSchultz, C.
dc.contributor.authorDang, J.
dc.contributor.authorAlasady, M.
dc.contributor.authorLau, D.
dc.contributor.authorBrooks, A.
dc.contributor.authorWong, C.
dc.contributor.authorRoberts-Thomson, K.
dc.contributor.authorYoung, G.
dc.contributor.authorWorthley, M.
dc.contributor.authorSanders, P.
dc.contributor.authorWilloughby, S.
dc.date.issued2014
dc.description.abstractBACKGROUND: Inflammation has been linked to the genesis of stroke in atrial fibrillation (AF) and is implicated in early recurrent arrhythmia after AF ablation. We aimed to define the time course of inflammation, myocardial injury, and prothrombotic markers after radiofrequency ablation for AF and its relation to AF recurrence. METHODS AND RESULTS: Ninety consecutive AF patients (53% paroxysmal) undergoing radiofrequency ablation were recruited. High-sensitivity C-reactive protein (hs-CRP), Troponin-T, creatine kinase-MB, fibrinogen, and D-Dimer concentrations were measured at baseline, at 1, 2, 3, 7 days, and at 1 month after ablation. AF recurrence was documented at 3 days and at 1, 3, and 6 months follow-up. Troponin-T and creatine kinase-MB peaked at day 1 after procedure (both P<0.05). Hs-CRP peaked at day 3 after procedure (P<0.05). Fibrinogen (P<0.05) and D-Dimer (P<0.05) concentrations were significantly elevated at 1 week after procedure. Ln hs-CRP elevation correlated with Ln Troponin-T and fibrinogen elevation. The extent of Ln hs-CRP, Ln Troponin-T, and fibrinogen elevation predicted early AF recurrence within 3 days after procedure (P<0.05, respectively), but not at 3 and 6 months. CONCLUSIONS: Patients undergoing radiofrequency ablation for AF exhibit an inflammatory response within 3 days. The extent of inflammatory response predicts early AF recurrence but not late recurrence. Prothrombotic markers are elevated at 1 week after ablation and may contribute to increased risk of early thrombotic events after AF ablation.
dc.description.statementofresponsibilityHan S. Lim, Carlee Schultz, Jerry Dang, Muayad Alasady, Dennis H. Lau, Anthony G. Brooks, Christopher X. Wong, Kurt C. Roberts-Thomson, Glenn D. Young, Matthew I. Worthley, Prashanthan Sanders, and Scott R. Willoughby
dc.identifier.citationCirculation: Arrhythmia and Electrophysiology, 2014; 7(1):83-89
dc.identifier.doi10.1161/CIRCEP.113.000876
dc.identifier.issn1941-3149
dc.identifier.issn1941-3084
dc.identifier.orcidLim, H. [0000-0002-8532-7891]
dc.identifier.orcidSchultz, C. [0000-0002-0026-9873]
dc.identifier.orcidLau, D. [0000-0001-7753-1318] [0000-0002-1564-439X]
dc.identifier.orcidWong, C. [0000-0002-1913-6675]
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]
dc.identifier.urihttp://hdl.handle.net/2440/94258
dc.language.isoen
dc.publisherAmerican Heart Association
dc.rights© American Heart Association, Inc
dc.source.urihttps://doi.org/10.1161/circep.113.000876
dc.subjectAtrial Fibrillation
dc.subjectcatheter ablation
dc.subjectInflammation
dc.subjectthrombosis
dc.titleTime course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation
dc.typeJournal article
pubs.publication-statusPublished

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