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Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness

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dc.contributor.authorMansoori, B.
dc.contributor.authorDuijf, P.H.G.
dc.contributor.authorMohammadi, A.
dc.contributor.authorNajafi, S.
dc.contributor.authorRoshani, E.
dc.contributor.authorShanehbandi, D.
dc.contributor.authorHajiasgharzadeh, K.
dc.contributor.authorShirjang, S.
dc.contributor.authorDitzel, H.J.
dc.contributor.authorKazemi, T.
dc.contributor.authorMokhtarzadeh, A.
dc.contributor.authorGjerstorff, M.F.
dc.contributor.authorBaradaran, B.
dc.date.issued2020
dc.description.abstractDespite improved therapeutic strategies for early-stage breast cancer, the most common cancer type in women, relapse remains common and the underlying mechanisms for this progression remain poorly understood. To gain more insight, we studied the DNA-binding protein HMGA2 in breast cancer development and stemness. We demonstrated that HMGA2 is overexpressed in breast cancer tissues at the mRNA and protein levels (P value <0.0001). HMGA2 knockdown and overexpression in breast cancer cells revealed that HMGA2 promotes cell proliferation and protects against apoptosis via the intrinsic pathway. HMGA2 knockdown also causes cell cycle arrest in G2/M phase. In addition, we found that HMGA2 increases breast cancer cell migration and invasion (P value <0.001) and promotes the acquisition of cancer stem cell features, both in vitro, in colony formation (P value <0.01) and spheroid assays, and in breast cancer tissues. Overexpression of HMGA2 in breast cancer spurs the acquisition of several hallmarks of cancer, including increased cell proliferation, migration, invasion and stemness, and decreased apoptosis. Thus, targeting HMGA2 could represent an effective strategy to block breast cancer progression.
dc.identifier.citationExpert Opinion on Therapeutic Targets, 2020; 24(3):255-265
dc.identifier.doi10.1080/14728222.2020.1736559
dc.identifier.issn1472-8222
dc.identifier.issn1744-7631
dc.identifier.urihttps://hdl.handle.net/11541.2/34400
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.fundingIran National Science Foundation 97011396
dc.relation.fundingTabriz University of Medical Sciences 58754
dc.relation.fundingNational Institute for Medical Research Development 971415
dc.rightsCopyright 2020 Informa UK Limited, trading as Taylor & Francis Group
dc.source.urihttps://doi.org/10.1080/14728222.2020.1736559
dc.subjectHMGA2
dc.subjectCD133
dc.subjectbreast cancer
dc.subjectproliferation
dc.subjectEMT
dc.subjectapoptosis
dc.subjectcell cycle
dc.subjectstemness
dc.titleOverexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916770930801831

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