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Predictors, treatment, and outcomes of non-Pseudomonas Gram-negative peritonitis

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dc.contributor.authorJarvis, E.
dc.contributor.authorHawley, C.
dc.contributor.authorMcDonald, S.
dc.contributor.authorBrown, F.
dc.contributor.authorRosman, J.
dc.contributor.authorWiggins, K.
dc.contributor.authorBannister, K.
dc.contributor.authorJohnson, D.
dc.date.issued2010
dc.description.abstractNon-Pseudomonas Gram-negative (NPGN) peritonitis is a frequent, serious complication of peritoneal dialysis; however, previous reports have been limited to small, single-center studies. To gain insight on the frequency, predictors, treatment, and outcomes of NPGN peritonitis, we analyzed data in the ANZDATA registry of all adult Australian peritoneal dialysis patients over a 39-month period using multivariate logistic and multilevel Poisson regressions. There were 837 episodes of NPGN peritonitis (23.3% of all peritonitis) that occurred in 256 patients. The most common organism isolated was Escherichia coli, but included Klebsiella, Enterobacter, Serratia, Acinetobacter, Proteus, and Citrobacter, with multiple organisms identified in a quarter of the patients. The principal risk factor was older age, with poorer clinical outcome predicted by older age and polymicrobial peritonitis. The overall antibiotic cure rate was 59%. NPGN peritonitis was associated with significantly higher risks of hospitalization, catheter removal, permanent transfer to hemodialysis, and death compared to other organisms contributing to peritonitis. Underlying bowel perforation requiring surgery was uncommon. Hence, we show that NPGN peritonitis is a frequent, serious complication of peritoneal dialysis, which is frequently associated with significant risks, including death. Its cure with antibiotics alone is less likely when multiple organisms are involved.
dc.description.statementofresponsibilityElizabeth M. Jarvis, Carmel M. Hawley, Stephen P. McDonald, Fiona G. Brown, Johan B. Rosman, Kathryn J. Wiggins, Kym M. Bannister and David W. Johnson
dc.identifier.citationKidney International, 2010; 78(4):408-414
dc.identifier.doi10.1038/ki.2010.149
dc.identifier.issn0085-2538
dc.identifier.issn1523-1755
dc.identifier.orcidMcDonald, S. [0000-0001-6103-1386]
dc.identifier.urihttp://hdl.handle.net/2440/63064
dc.language.isoen
dc.publisherBlackwell Publishing Inc
dc.rights© 2010 International Society of Nephrology
dc.source.urihttps://doi.org/10.1038/ki.2010.149
dc.subjectantibiotics
dc.subjectbacteria
dc.subjectcontinuous ambulatory peritoneal dialysis
dc.subjectenterobacteriaceae
dc.subjectmicrobiology
dc.subjectperitonitis
dc.titlePredictors, treatment, and outcomes of non-Pseudomonas Gram-negative peritonitis
dc.typeJournal article
pubs.publication-statusPublished

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