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Stimulus-responsiveness and drug release from porous silicon films ATRP-grafted with poly(N-isopropylacrylamide)

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dc.contributor.authorVasani, R.
dc.contributor.authorMcInnes, S.
dc.contributor.authorCole, M.
dc.contributor.authorJani, A.
dc.contributor.authorEllis, A.
dc.contributor.authorVoelcker, N.
dc.date.issued2011
dc.description.abstractIn this report, we employ surface-initiated atom transfer radical polymerization (SI-ATRP) to graft a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAM), of controlled thickness from porous silicon (pSi) films to produce a stimulus-responsive inorganic-organic composite material. The optical properties of this material are studied using interferometric reflectance spectroscopy (IRS) above and below the lower critical solution temperature (LCST) of the PNIPAM graft polymer with regard to variation of pore sizes and thickness of the pSi layer (using discrete samples and pSi gradients) and also the thickness of the PNIPAM coatings. Our investigations of the composite's thermal switching properties show that pore size, pSi layer thickness, and PNIPAM coating thickness critically influence the material's thermoresponsiveness. This composite material has considerable potential for a range of applications including temperature sensors and feedback controlled drug release. Indeed, we demonstrate that modulation of the temperature around the LCST significantly alters the rate of release of the fluorescent anticancer drug camptothecin from the pSi-PNIPAM composite films.
dc.identifier.citationLangmuir, 2011; 27(12):7843-7853
dc.identifier.doi10.1021/la200551g
dc.identifier.issn0743-7463
dc.identifier.issn1520-5827
dc.identifier.urihttps://hdl.handle.net/1959.8/122478
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.relation.fundingSouth Australian Premier's Science and Research Council
dc.rightsCopyright 2011 American Chemical Society
dc.source.urihttps://doi.org/10.1021/la200551g
dc.subjectSilicon
dc.subjectAcrylamides
dc.subjectCamptothecin
dc.subjectPolymers
dc.subjectAntineoplastic Agents
dc.subjectPharmaceutical Preparations
dc.subjectMicroscopy, Electron, Scanning
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.subjectSpectrophotometry, Ultraviolet
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectThermogravimetry
dc.titleStimulus-responsiveness and drug release from porous silicon films ATRP-grafted with poly(N-isopropylacrylamide)
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915909404201831

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