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Regulating life after death: how mechanical communication mediates the epithelial response to apoptosis

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dc.contributor.authorBonfim Melo, A.
dc.contributor.authorDuszyc, K.
dc.contributor.authorGomez, G.A.
dc.contributor.authorYap, A.S.
dc.date.issued2022
dc.description.abstractIt is increasingly evident that cells in tissues and organs can communicate with one another using mechanical forces. Such mechanical signalling can serve as a basis for the assembly of cellular communities. For this to occur, there must be local instabilities in tissue mechanics that are the source of the signals, and mechanisms for changes in mechanical force to be transmitted and detected within tissues. In this review, we discuss these principles using the example of cell death by apoptosis, when it occurs in epithelia. This elicits the phenomenon of apical extrusion, which can rapidly eliminate apoptotic cells by expelling them from the epithelium. Apoptotic extrusion requires that epithelial cells detect the presence of nearby apoptotic cells, something which can be elicited by the mechanotransduction of tensile instabilities caused by the apoptotic cell. We discuss the central role that adherens junctions can play in the transmission and detection of mechanical signals from apoptotic cells.
dc.identifier.citationEuropean Physical Journal E, 2022; 45(1, article no. 9):1-8
dc.identifier.doi10.1140/epje/s10189-022-00163-9
dc.identifier.issn1292-8941
dc.identifier.issn1292-895X
dc.identifier.urihttps://hdl.handle.net/11541.2/27141
dc.language.isoen
dc.publisherSpringer
dc.relation.fundingNHMRC 1164462
dc.relation.fundingNHMRC 1136592
dc.relation.fundingARC DP19010287
dc.relation.fundingARC FT160100366
dc.relation.fundingCharlie Teo Foundation
dc.relation.fundingCure Brain Cancer Foundation
dc.relation.fundingThe Medical Advances Without Animals Trust (MAWA)
dc.relation.fundingNeuroSurgical Research Foundation
dc.rightsCopyright 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1140/epje/s10189-022-00163-9
dc.subjectadherens junction
dc.subjectapoptosis
dc.subjectepithelium
dc.subjectepithelium cell
dc.subjectinterpersonal communication
dc.subjectmechanotransduction
dc.subjectcells
dc.subjectmechanical signalling
dc.subjecttissues
dc.subjectorgans
dc.subjectapical extrusion
dc.titleRegulating life after death: how mechanical communication mediates the epithelial response to apoptosis
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12239837800001831 13239837790001831 Bonfim-Melo2022_Article_RegulatingLifeAfterDeathHowMec
ror.mmsid9916606250501831

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