Performance of using deformability of endometrial cells as a diagnostic test for endometriosis
Date
2019
Authors
Altayyeb, A.
Othman, E.
Khashbah, M.
Esmaeel, A.
El Mokhtar, M.
Lambalk, C.
Mijatovic, V.
Abdelgawad, M.
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Advisors
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Type:
Conference paper
Citation
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, 2019, pp.1586-1587
Statement of Responsibility
Conference Name
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (27 Oct 2019 - 31 Oct 2019 : Basel, Switzerland)
Abstract
We present a microfluidic platform for less-invasive diagnosis of endometriosis based on measuring deformability of eutopic endometrial stromal cells. Primary endometrial cells from patients were found to travel inside a narrow microchannel at a significantly higher velocity (96.5 mm/s) compared to cells from disease free women (57.52 mm/s) (P value < 0.001). Using velocity of endometrial cells as a biomarker of endometriosis gave a sensitivity of 100%, and a specificity of 83%. Instead of doing a laparoscopic surgery, our test reduces cost of diagnosis of endometriosis to only few dollars with the proper setup.
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Copyright 2019 Chemical and Biological Microsystems Society