Association of reaction symptoms and eliciting dose with health-related quality of life in children with peanut allergy

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dc.contributor.authorHu, A.
dc.contributor.authorLloyd, M.
dc.contributor.authorLoke, P.
dc.contributor.authorChebar Lozinsky, A.
dc.contributor.authorO'Sullivan, M.
dc.contributor.authorQuinn, P.
dc.contributor.authorGold, M.
dc.contributor.authorTang, M.L.
dc.date.issued2023
dc.descriptionAvailable online July 7, 2023
dc.description.abstractBACKGROUND: Food allergy adversely affects the healthrelated quality of life (HRQoL) of patients. It is unclear whether factors such as the reaction eliciting dose (ED) and the nature of allergic reaction symptoms affect HRQoL. OBJECTIVE: To explore associations between reaction ED or the nature of allergic symptoms and HRQoL among children with peanut allergy. METHODS: This study was a secondary analysis of baseline data from the PPOIT-003 randomized trial in 212 children aged 1 to 10 years with challenge-confirmed peanut allergy. Children’s past reaction symptoms were collected by clinicians during screening. Associations between variables of interest and parentreported child-proxy HRQoL were examined by univariable and multivariable linear regression. RESULTS: Mean age of study participants was 5.9 years; 63.2% were male. Children with a low reaction ED of 80 mg peanut protein had significantly poorer HRQoL (b [ e0.81; 95% CI, e1.61 to e0.00; P [ .049) compared with children with a high ED of 2,500 mg peanut protein. Gastrointestinal symptoms (b [ 0.45; 95% CI, 0.03-0.87; P [ .037), lower airway symptoms (b [ 0.46; 95% CI, 0.05-0.87; P [ .030), multisystem involvement (b [ 0.71; 95% CI, 0.25-1.16; P ¼ .003), or anaphylaxis (b ¼ 0.46; 95% CI, 0.04-0.87; P ¼ .031) during a previous reaction were associated with worse HRQoL. CONCLUSIONS: Peanut-allergic children with a lower allergen reaction threshold experienced a greater negative HRQoL impact compared with children with higher reaction thresholds. In addition, specific past allergic reaction symptoms were associated with comparatively worse HRQoL. Children experiencing these symptoms and those with lower reaction ED require increased clinical support to manage the food allergy and are likely to benefit from interventions that can improve HRQoL.
dc.description.statementofresponsibilityAlice Hu, Melanie Lloyd, Paxton Loke, Adriana Chebar Lozinsky, Michael O, Sullivan, Patrick Quinn, Michael Gold, and Mimi L.K. Tang
dc.identifier.citationJournal of Allergy and Clinical Immunology: In Practice, 2023; 11(10):3195-3202.e4
dc.identifier.doi10.1016/j.jaip.2023.06.063
dc.identifier.issn2213-2198
dc.identifier.issn2213-2201
dc.identifier.orcidGold, M. [0000-0003-1312-5331]
dc.identifier.urihttps://hdl.handle.net/2440/139158
dc.language.isoen
dc.publisherElsevier
dc.relation.grantNHMRC
dc.rights© 2023 American Academy of Allergy, Asthma & Immunology
dc.source.urihttps://doi.org/10.1016/j.jaip.2023.06.063
dc.subjectFood allergy; Peanut allergy; Quality of life; Eliciting dose; Allergic reaction symptoms
dc.titleAssociation of reaction symptoms and eliciting dose with health-related quality of life in children with peanut allergy
dc.typeJournal article
pubs.publication-statusPublished

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