Diagnostic approaches, aetiological agents and their associations with short-term survival and laminitis in horses with acute diarrhoea admitted to referral institutions

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dc.contributor.authorGomez, D.
dc.contributor.authorArroyo, L.G.
dc.contributor.authorSchoster, A.
dc.contributor.authorRenaud, D.L.
dc.contributor.authorKopper, J.J.
dc.contributor.authorDunkel, B.
dc.contributor.authorByrne, D.
dc.contributor.authorMykkanen, A.
dc.contributor.authorGilsenan, W.F.
dc.contributor.authorPihl, T.H.
dc.contributor.authorLopez, G.
dc.contributor.authorTennent-Brown, B.S.
dc.contributor.authorHostnik, L.D.
dc.contributor.authorMora-Pereira, M.
dc.contributor.authorMarquez, F.
dc.contributor.authorGold, J.R.
dc.contributor.authorDeNotta, S.L.
dc.contributor.authorDesjardins, I.
dc.contributor.authorStewart, A.J.
dc.contributor.authorKuroda, T.
dc.contributor.authoret al.
dc.date.issued2024
dc.descriptionFirst published: 20 November 2023
dc.description.abstractBackground: An international description of the diagnostic approaches used in different institutions to diagnose acute equine diarrhoea and the pathogens detected is lacking. Objectives: To describe the diagnostic approach, aetiological agents, outcome, and development of laminitis for diarrhoeic horses worldwide. Study design: Multicentre retrospective case series. Methods: Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020, including diagnostic approaches, pathogens detected and their associations with outcomes, were compared between institutions or geographic regions. Results: One thousand four hundred and thirty-eight horses from 26 participating institutions from 4 continents were included. Overall, aetiological testing was limited (44% for Salmonella spp., 42% for Neorickettsia risticii [only North America], 40% for Clostridiodes difficile, and 29% for ECoV); however, 13% (81/633) of horses tested positive for Salmonella, 13% (35/262) for N. risticii, 9% (37/422) for ECoV, and 5% (27/578) for C. difficile. C. difficile positive cases had greater odds of non-survival than horses negative for C. difficile (OR: 2.69, 95%CI: 1.23–5.91). In addition, horses that were positive for N. risticii had greater odds of developing laminitis than negative horses (OR: 2.76, 95%CI: 1.12–6.81; p = 0.029). Main limitations: Due to the study's retrospective nature, there are missing data. Conclusions: This study highlighted limited diagnostic investigations in cases of acute equine diarrhoea. Detection rates of pathogens are similar to previous reports. Nonsurvival and development of laminitis are related to certain detected pathogens.
dc.description.statementofresponsibilityDiego E. Gomez, Luis G. Arroyo, Angelika Schoster, David L. Renaud, Jamie J. Kopper, Bettina Dunkel, David Byrne, The MEDS group: Anna Mykkanen ... Gustavo Ferlini Agne ... et al.
dc.identifier.citationEquine Veterinary Journal, 2024; 56(5):959-969
dc.identifier.doi10.1111/evj.14024
dc.identifier.issn0425-1644
dc.identifier.issn0425-1644
dc.identifier.orcidFerlini Agne, G. [0000-0002-4386-9916]
dc.identifier.urihttps://hdl.handle.net/2440/140029
dc.language.isoen
dc.publisherWiley
dc.rights© 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.source.urihttps://doi.org/10.1111/evj.14024
dc.subjectantimicrobial associated diarrhoea; Clostridiosis; horse; Potomac horse fever; sand diarrhoea
dc.titleDiagnostic approaches, aetiological agents and their associations with short-term survival and laminitis in horses with acute diarrhoea admitted to referral institutions
dc.typeJournal article
pubs.publication-statusPublished

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