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Very low-fat (12%) and high monounsaturated fat (35%) diets do not differentially affect abdominal fat loss in overweight, nondiabetic women

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dc.contributor.authorClifton, P.
dc.contributor.authorNoakes, M.
dc.contributor.authorKeogh, J.
dc.date.issued2004
dc.description.abstractStudies in women with type 2 diabetes demonstrated adverse effects on body fat distribution of a low-fat diet relative to a high monounsaturated fat diet. We performed a randomized 12-wk parallel design study of two 6000-kJ diets: 35% energy from fat (high monounsaturated fat diet, HIMO), or 12% energy from fat (very low-fat diet, VLF) to determine whether this also occurred in nondiabetic women. Body fat distribution, fasting plasma glucose, blood pressure, and fasting serum lipids were measured at wk 0 and 12 in 62 women (BMI > 27 kg/m(2)). Weight loss (9.5 +/- 2.4 vs. 9.4 +/- 3.4 kg, VLF vs. HIMO) and total fat loss (6.1 +/- 2.4 vs. 6.3 +/- 2.7 kg, VLF vs. HIMO) did not differ in the groups. There was a diet x menopausal status interaction in lean mass changes (P = 0.005) such that in premenopausal women, HIMO produced a lower loss of lean mass than the low-fat diet (0.4 +/- 2.3 vs. 2.9 +/- 2.7 kg, P = 0.006) with the opposite but nonsignificant effect seen in postmenopausal women. There was a greater decrease in total plasma cholesterol in women who consumed VLF compared with those who consumed HIMO (0.82 +/- 0.0.51 vs. 0.50 +/- 0.48 mmol/L, P < 0.001 for time, P < 0.05 for diet effect). This was also true for the change in HDL cholesterol (0.18 +/- 0.23 vs. 0.04 +/- 0.19 mmol/L, VLF and HIMO, respectively, P < 0.001 for time, P < 0.05 for diet effect). The LDL/HDL ratio was reduced in both groups with no effect of diet (0.16 +/- 0.51 vs. 0.16 +/- 0.45, VLF and HIMO, respectively, P < 0.05). In conclusion, weight, total fat mass, and regional fat mass loss did not differ in the 2 groups of women but there was an apparent preservation of lean mass in premenopausal women consuming HIMO.
dc.identifier.citationJournal of Nutrition, 2004; 134(7):1741-1745
dc.identifier.doi10.1093/jn/134.7.1741
dc.identifier.issn0022-3166
dc.identifier.issn1541-6100
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]
dc.identifier.urihttp://hdl.handle.net/2440/9634
dc.language.isoen
dc.publisherAmer Inst Nutrition
dc.source.urihttps://doi.org/10.1093/jn/134.7.1741
dc.subjectHumans
dc.subjectObesity
dc.subjectInsulin
dc.subjectBlood Glucose
dc.subjectLipids
dc.subjectDietary Fats
dc.subjectFatty Acids, Monounsaturated
dc.subjectBody Mass Index
dc.subjectDiet
dc.subjectTissue Distribution
dc.subjectPostmenopause
dc.subjectPremenopause
dc.subjectBlood Pressure
dc.subjectMiddle Aged
dc.subjectFemale
dc.titleVery low-fat (12%) and high monounsaturated fat (35%) diets do not differentially affect abdominal fat loss in overweight, nondiabetic women
dc.typeJournal article
pubs.publication-statusPublished

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