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Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma

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dc.contributor.authorCoyle, P.
dc.contributor.authorMathew, G.
dc.contributor.authorGame, P.
dc.contributor.authorMyers, J.
dc.contributor.authorPhilcox, J.
dc.contributor.authorRofe, A.
dc.contributor.authorJamieson, G.
dc.date.issued2002
dc.description© 2002 Cancer Research, UK
dc.description.abstractThe potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively determined in resected tissues from patients undergoing oesophagectomy for high grade dysplasia/carcinoma and in biopsies from patients with Barrett's syndrome. In 10 cancer patients, metallothionein concentrations in adenocarcinoma were not significantly different from normal oesophagus, although six had elevated metallothionein concentrations in the metaplastic tissue bordering the adenocarcinoma. In 17 out of 20 non-cancer patients with Barrett's epithelium, metallothionein was significantly increased by 108% (P<0.004). There was no association between the metallothionein levels in Barrett's epithelium and the presence of inflammatory cells, metaplasia or dysplasia. Metallothionein is a marker of progression from normal to Barrett's epithelium but is not increased in oesophageal adenocarcinoma.
dc.description.statementofresponsibilityP. Coyle, G. Mathew, P.A. Game, J.C. Myers, J.C. Philcox, A.M. Rofe and G.G. Jamieson
dc.identifier.citationBritish Journal of Cancer, 2002; 87(5):533-536
dc.identifier.doi10.1038/sj.bjc.6600473
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.orcidMyers, J. [0000-0003-2157-7098]
dc.identifier.urihttp://hdl.handle.net/2440/10541
dc.language.isoen
dc.publisherChurchill Livingstone
dc.source.urihttps://doi.org/10.1038/sj.bjc.6600473
dc.subjectmetallothionein
dc.subjectBarrett's oesophagus
dc.subjectadenocarcinoma
dc.subjectrisk factors
dc.titleMetallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
dc.typeJournal article
pubs.publication-statusPublished

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