Multiple functions of CXCL12 in a syngeneic model of breast cancer

Simple item page
dc.contributor.authorWilliams, S.
dc.contributor.authorHarata-Lee, Y.
dc.contributor.authorAnderson, R.
dc.contributor.authorComerford, I.
dc.contributor.authorSmyth, M.
dc.contributor.authorMcColl, S.
dc.date.issued2010
dc.description.abstractBACKGROUND: A growing body of work implicates chemokines, in particular CXCL12 and its receptors, in the progression and site-specific metastasis of various cancers, including breast cancer. Various agents have been used to block the CXCL12-CXCR4 interaction as a means of inhibiting cancer metastasis. However, as a potent chemotactic factor for leukocytes, CXCL12 also has the potential to enhance anti-cancer immunity. To further elucidate its role in breast cancer progression, CXCL12 and its antagonist CXCL12(P2G) were overexpressed in the syngeneic 4T1.2 mouse model of breast carcinoma. RESULTS: While expression of CXCL12(P2G) significantly inhibited metastasis, expression of wild-type CXCL12 potently inhibited both metastasis and primary tumor growth. The effects of wild-type CXCL12 were attributed to an immune response characterized by the induction of CD8+ T cell activity, enhanced cell-mediated cytotoxicity, increased numbers of CD11c+ cells in the tumor-draining lymph nodes and reduced accumulation of myeloid-derived suppressor cells in the spleen.CONCLUSIONS: This study highlights the need to consider carefully therapeutic strategies that block CXCL12 signaling. Therapies that boost CXCL12 levels at the primary tumor site may prove more effective in the treatment of metastatic breast cancer.
dc.description.statementofresponsibilitySharon A Williams, Yuka Harata-Lee, Iain Comerford, Robin L Anderson, Mark J Smyth and Shaun R McColl
dc.identifier.citationMolecular Cancer, 2010; 9(250):1-10
dc.identifier.doi10.1186/1476-4598-9-250
dc.identifier.issn1476-4598
dc.identifier.issn1476-4598
dc.identifier.orcidMcColl, S. [0000-0003-0949-4660]
dc.identifier.urihttp://hdl.handle.net/2440/61297
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.rights© 2010 Williams et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1186/1476-4598-9-250
dc.subjectDendritic Cells
dc.subjectCell Line, Tumor
dc.subjectAnimals
dc.subjectMice, Inbred BALB C
dc.subjectMice
dc.subjectMice, SCID
dc.subjectBreast Neoplasms
dc.subjectReceptors, CXCR4
dc.subjectFlow Cytometry
dc.subjectImmunohistochemistry
dc.subjectCell Proliferation
dc.subjectFemale
dc.subjectChemokine CXCL12
dc.titleMultiple functions of CXCL12 in a syngeneic model of breast cancer
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_61297.pdf
Size:
2.11 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Molecular and Biomedical Science publications
IPAS publications