Label-free Si3N4 photonic crystal based immunosensors for diagnostic applications
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Date
2014
Authors
Zecca, D.
Qualtieri, A.
Magno, G.
Grande, M.
Petruzzelli, V.
Prieto Simon, B.
D'Orazio, A.
De Vittorio, M.
Voelcker, N.H.
Stomeo, T.
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IEEE Photonics Journal, 2014; 6(6):1-8
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Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.
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Copyright 2014 IEEE