Artificial cells for the treatment of liver diseases

Simple item page
dc.contributor.authorZou, D.
dc.contributor.authorWang, H.
dc.contributor.authorLiu, X.
dc.contributor.authorXu, Z.P.
dc.contributor.authorRoberts, M.S.
dc.contributor.authorZhao, C.X.
dc.date.issued2021
dc.description.abstractLiver diseases have become an increasing health burden and account for over 2 million deaths every year globally. Standard therapies including liver transplant and cell therapy offer a promising treatment for liver diseases, but they also suffer limitations such as adverse immune reactions and lack of long-term efficacy. Artificial cells that mimic certain functions of a living cell have emerged as a new strategy to overcome some of the challenges that liver cell therapy faces at present. Artificial cells have demonstrated advantages in long-term storage, targeting capability, and tuneable features. This article provides an overview of the recent progress in developing artificial cells and their potential applications in liver disease treatment. First, the design of artificial cells and their biomimicking functions are summarized. Then, systems that mimic cell surface properties are introduced with two concepts highlighted: cell membrane-coated artificial cells and synthetic lipid-based artificial cells. Next, cell microencapsulation strategy is summarized and discussed. Finally, challenges and future perspectives of artificial cells are outlined. STATEMENT OF SIGNIFICANCE: Liver diseases have become an increasing health burden. Standard therapies including liver transplant and cell therapy offer a promising treatment for liver diseases, but they have limitations such as adverse immune reactions and lack of long-term efficacy. Artificial cells that mimic certain functions of a living cell have emerged as a new strategy to overcome some of the challenges that liver cell therapy faces at present. This article provides an overview of the recent progress in developing artificial cells and their potential applications in liver disease treatment, including the design of artificial cells and their biomimicking functions, two systems that mimic cell surface properties (cell membrane-coated artificial cells and synthetic lipid-based artificial cells), and cell microencapsulation strategy. We also outline the challenges and future perspectives of artificial cells.
dc.description.statementofresponsibilityDa Zou, Haolu Wang, Xin Liu, Zhi Ping Xu, Michael S.Roberts, Chun-Xia Zhao
dc.identifier.citationActa Biomaterialia, 2021; 130:98-114
dc.identifier.doi10.1016/j.actbio.2021.06.012
dc.identifier.issn1742-7061
dc.identifier.issn1878-7568
dc.identifier.orcidZou, D. [0000-0002-4425-3574]
dc.identifier.urihttps://hdl.handle.net/2440/132901
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1126091
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1141121
dc.relation.granthttp://purl.org/au-research/grants/arc/FT140100726
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200101238
dc.rights© 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.actbio.2021.06.012
dc.subjectArtificial cell
dc.subjectbiomimetic
dc.subjectcell therapy
dc.subjectliver diseases
dc.subject.meshCell Membrane
dc.subject.meshHepatocytes
dc.subject.meshHumans
dc.subject.meshLiver Diseases
dc.subject.meshArtificial Cells
dc.titleArtificial cells for the treatment of liver diseases
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Chemical Engineering publications