Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
Date
2005
Authors
O'Connor, C.
Cernak, I.
Vink, R.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Brain Research, 2005; 1062(1-2):171-174
Statement of Responsibility
Christine A. O'Connora, Ibolja Cernakc and Robert Vink
Conference Name
Abstract
Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the present study, we demonstrate in both male and ovariectomized female rats that a single physiological dose of either hormone at 30 min after diffuse traumatic brain injury reduces both blood brain barrier permeability and edema formation. We conclude that both hormones may contribute to reduce edema in females after brain injury.
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Dissertation Note
Provenance
Description
Available online 26 October 2005.
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Rights
Copyright © 2005 Elsevier B.V. All rights reserved.