Current studentsExisting staffContact us
 

Inguinal and ilio-inguinal lymphadenectomy in management of palpable melanoma lymph node metastasis: a long-term prospective evaluation of morbidity and quality of life

Simple item page
dc.contributor.authorHenderson, M.A.
dc.contributor.authorGyorki, D.
dc.contributor.authorBurmeister, B.H.
dc.contributor.authorAinslie, J.
dc.contributor.authorFisher, R.
dc.contributor.authorDi Iulio, J.
dc.contributor.authorSmithers, B.M.
dc.contributor.authorHong, A.
dc.contributor.authorShannon, K.
dc.contributor.authorScolyer, R.A.
dc.contributor.authorCarruthers, S.
dc.contributor.authorCoventry, B.J.
dc.contributor.authorBabington, S.
dc.contributor.authorDuprat, J.
dc.contributor.authorHoekstra, H.J.
dc.contributor.authorThompson, J.F.
dc.date.issued2019
dc.description.abstractPurpose: Prospective data are lacking on long-term morbidity of inguinal lymphadenectomy including the influence of extent of surgery, use of radiotherapy, and patient factors. The aim of this study is to evaluate the effects of these factors on patient outcome, quality of life (QOL), regional symptoms, and limb volumes after inguinal or ilio-inguinal lymphadenectomy for melanoma. Methods: Analysis of the subgroup of patients with inguinal lymph node field relapse of melanoma, treated by inguinal or ilio-inguinal lymphadenectomy in the ANZMTG/TROG randomized trial of adjuvant radiotherapy versus observation. Results: Sixty-nine patients, 46 having undergone inguinal and 23 ilio-inguinal lymphadenectomy, with median follow-up of 73 months were analyzed. Mean limb volume increased rapidly after surgery (7% by 3 months) and continued to increase for at least another 18 months. Patients with body mass index (BMI) ≥ 25 kg/m2 had greater limb volume increase than normal-weight patients (13.3% versus 6.9%, P = 0.030). QOL improved over the first 18 months, but despite initial improvement, regional symptoms persisted long term. Type of surgery (inguinal or ilio-inguinal lymphadenectomy) had no demonstrably significant effect on limb volume (9.9% versus 13.4%, P = 0.35), QOL (P = 0.68), or regional symptoms (P = 0.65). There was no difference in overall survival between inguinal and ilio-inguinal lymphadenectomy [hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.40-1.40, P = 0.43]. Conclusions: Inguinal lymphadenectomy for melanoma is a potentially morbid procedure with significant increases in limb volume. Patients report reasonable QOL but may have ongoing regional symptoms. Overweight/obesity is associated with poorer QOL, increased limb volume, and regional symptoms.
dc.description.statementofresponsibilityMichael A. Henderson, D. Gyorki, B.H. Burmeister, J. Ainslie, R. Fisher, J. Di Iulio, B.M. Smithers, A. Hong, K. Shannon, R.A. Scolyer, S. Carruthers, B.J. Coventry, S. Babington, J. Duprat, H.J. Hoekstra, and J.F. Thompson
dc.identifier.citationAnnals of Surgical Oncology, 2019; 26(13):4663-4672
dc.identifier.doi10.1245/s10434-019-07810-0
dc.identifier.issn1068-9265
dc.identifier.issn1534-4681
dc.identifier.orcidCoventry, B.J. [0000-0002-3596-7735]
dc.identifier.urihttp://hdl.handle.net/2440/123456
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.grantNHMRC
dc.rights© Society of Surgical Oncology 2019
dc.source.urihttps://doi.org/10.1245/s10434-019-07810-0
dc.subjectInguinal Canal
dc.subjectIlium
dc.subjectLymph Nodes
dc.subjectHumans
dc.subjectMelanoma
dc.subjectLymphatic Metastasis
dc.subjectPrognosis
dc.subjectLymph Node Excision
dc.subjectMorbidity
dc.subjectSurvival Rate
dc.subjectFollow-Up Studies
dc.subjectProspective Studies
dc.subjectQuality of Life
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectDisease Management
dc.subjectFemale
dc.subjectMale
dc.titleInguinal and ilio-inguinal lymphadenectomy in management of palpable melanoma lymph node metastasis: a long-term prospective evaluation of morbidity and quality of life
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications