Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care

Simple item page
dc.contributor.authorGebremichael, L.G.
dc.contributor.authorSuppiah, V.
dc.contributor.authorWiese, M.D.
dc.contributor.authorMackenzie, L.
dc.contributor.authorPhillips, C.
dc.contributor.authorWilliams, D.B.
dc.contributor.authorRoberts, M.S.
dc.date.issued2021
dc.description.abstractAlthough statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerability vary among statins in different ethnic groups. Indigenous Australians have a high risk for cardiovascular and kidney diseases. Prescribing statins to Indigenous Australians with multi-morbidity requires different strategies to increase efficacy and reduce their toxicity. Previous studies have reported that Indigenous Australians are more susceptible to severe statin-induced myopathies. However, there is a lack of evidence in the underlying genetic factors in this population. This review aims to identify: inter-ethnic differences in the efficacy and safety of statins; major contributing factors accounting for any identified differences; and provide an overview of statin-induced adverse effects in Indigenous Australians.
dc.description.statementofresponsibilityLemlem G Gebremichael, Vijayaprakash Suppiah, Michael D Wiese, Lorraine Mackenzie, Craig Phillips, Desmond B Williams, Michael S Roberts
dc.identifier.citationPharmacogenomics, 2021; 22(9):553-571
dc.identifier.doi10.2217/pgs-2020-0152
dc.identifier.issn1462-2416
dc.identifier.issn1744-8042
dc.identifier.orcidSuppiah, V. [0000-0001-5496-935X]
dc.identifier.urihttp://hdl.handle.net/2440/131071
dc.language.isoen
dc.publisherFuture Medicine
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1107356
dc.rights© 2021 Future Medicine Ltd.
dc.source.urihttps://doi.org/10.2217/pgs-2020-0152
dc.subjectIndigenous
dc.subjectethnic groups
dc.subjectpharmacogenetics
dc.subjectsafety
dc.subjectstatin
dc.titleEfficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Biochemistry publications