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Rising incidence of early-onset colorectal cancer in Australia over two decades: Report and review

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dc.contributor.authorYoung, J.
dc.contributor.authorWin, A.
dc.contributor.authorRosty, C.
dc.contributor.authorFlight, I.
dc.contributor.authorRoder, D.
dc.contributor.authorYoung, G.
dc.contributor.authorFrank, O.
dc.contributor.authorSuthers, G.
dc.contributor.authorHewett, P.
dc.contributor.authorRuszkiewicz, A.
dc.contributor.authorHauben, E.
dc.contributor.authorAdelstein, B.
dc.contributor.authorParry, S.
dc.contributor.authorTownsend, A.
dc.contributor.authorHardingham, J.
dc.contributor.authorPrice, T.
dc.date.issued2015
dc.descriptionLink to a related website: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgh.12792, Open Access via Unpaywall
dc.description.abstractThe average age at diagnosis for colorectal cancer (CRC) in Australia is 69, and the age-specific incidence rises rapidly after age 50 years. The incidence has stabilized or is declining in older age groups in Australia during recent decades, possibly related to the increased uptake of screening and high-risk surveillance. In the same time frame, a rising incidence of CRC in younger adults has been well-documented in the United States. This rise in incidence in the young has not been reported from other countries that share long-term exposure to westernised urban lifestyles. Using data from the Australian Institute of Health and Welfare, we examined trends in national incidence rates for CRC under age 50 years and observed that rates in people under age 40 years have been rising for the last two decades. We further performed a review of the literature regarding CRC in young adults to outline the extent of current understanding, explore potential risk factors such as obesity, alcohol, and sedentary lifestyles, and to identify the questions remaining to be addressed. Although absolute numbers might not justify a population screening approach, the dispersal of young adults with CRC across the primary health-care system decreases probability of their recognition. Patient and physician awareness, aided by stool and emerging blood-screening tests and risk profiling tools, have the potential to aid in identification of those young adults who would most benefit from a colonoscopy through early detection of CRCs or by removal of advanced polyps.
dc.description.statementofresponsibilityJoanne P Young, Aung Ko Win, Christophe Rosty, Ingrid Flight, David Roder, Graeme P Young, Oliver Frank, Graeme K Suthers, Peter J Hewett, Andrew Ruszkiewicz, Ehud Hauben, Barbara-Ann Adelstein, Susan Parry, Amanda Townsend, Jennifer E Hardingham and Timothy J Price
dc.identifier.citationJournal of Gastroenterology and Hepatology (Australia), 2015; 30(1):6-13
dc.identifier.doi10.1111/jgh.12792
dc.identifier.issn0815-9319
dc.identifier.issn1440-1746
dc.identifier.orcidYoung, J. [0000-0002-1514-1522]
dc.identifier.orcidRoder, D. [0000-0001-6442-4409]
dc.identifier.orcidFrank, O. [0000-0001-9028-1835]
dc.identifier.orcidRuszkiewicz, A. [0000-0001-9052-4948]
dc.identifier.orcidHauben, E. [0000-0002-6062-411X]
dc.identifier.orcidTownsend, A. [0000-0003-3563-4719]
dc.identifier.orcidHardingham, J. [0000-0001-8277-1199]
dc.identifier.orcidPrice, T. [0000-0002-3922-2693]
dc.identifier.urihttp://hdl.handle.net/2440/90774
dc.language.isoen
dc.publisherWiley
dc.rights© 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
dc.source.urihttps://doi.org/10.1111/jgh.12792
dc.subjectearly-onset colorectal cancer
dc.subjectoutcomes
dc.subjectpresentation
dc.subjectrisk factors
dc.titleRising incidence of early-onset colorectal cancer in Australia over two decades: Report and review
dc.typeJournal article
pubs.publication-statusPublished

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