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Past medical history and pancreatic cancer risk: Results from a multicenter case-control study

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dc.contributor.authorMaisonneuve, P.
dc.contributor.authorLowenfels, A.
dc.contributor.authorBueno-de-Mesquita, H.
dc.contributor.authorGhadirian, P.
dc.contributor.authorBaghurst, P.
dc.contributor.authorZatonski, W.
dc.contributor.authorMiller, A.
dc.contributor.authorDuell, E.
dc.contributor.authorBoffetta, P.
dc.contributor.authorBoyle, P.
dc.date.issued2010
dc.description.abstract<h4>Purpose</h4>To investigate risk factors that may be linked to pancreatic cancer.<h4>Methods</h4>We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland.<h4>Results</h4>After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82).<h4>Conclusions</h4>Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.
dc.description.statementofresponsibilityPatrick Maisonneuve, Albert B. Lowenfels, H. Bas Bueno-De-Mesquita, Parviz Ghadirian, Peter A. Baghurst, Witold A. Zatonski, Anthony B. Miller, Eric J. Duell, Paolo Boffetta, and Peter Boyle
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505746/description#description
dc.identifier.citationAnnals of Epidemiology, 2010; 20(2):92-98
dc.identifier.doi10.1016/j.annepidem.2009.11.010
dc.identifier.issn1047-2797
dc.identifier.issn1873-2585
dc.identifier.urihttp://hdl.handle.net/2440/63032
dc.language.isoen
dc.publisherElsevier Science Inc
dc.rightsCopyright 2010 Elsevier Inc.
dc.source.urihttps://doi.org/10.1016/j.annepidem.2009.11.010
dc.subjectAllergies
dc.subjectDiabetes
dc.subjectMulticenter Case-Control Study
dc.subjectPancreas Cancer
dc.subjectPancreatitis
dc.subjectPast Medical History
dc.titlePast medical history and pancreatic cancer risk: Results from a multicenter case-control study
dc.typeJournal article
pubs.publication-statusPublished

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