Change in liver size and fat content after treatment with Optifast Very Low Calorie Diet

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dc.contributor.authorLewis, M.
dc.contributor.authorPhillips, M.
dc.contributor.authorSlavotinek, J.
dc.contributor.authorKow, L.
dc.contributor.authorThompson, C.
dc.contributor.authorToouli, J.
dc.date.issued2006
dc.description.abstractBackground: Laparoscopic adjustable gastric banding (LAGB) requires surgical access to the gastroesophageal junction, which may be compromised by the enlarged, fatty liver that is frequently encountered in the obese. Liver size appears reduced and surgical access improved following preoperative weight loss with Optifast® Very Low Calorie Diet (VLCD). The aim of this study was to assess the effects of 6 weeks Optifast® VLCD on liver volume and fat content. Methods: 18 morbidly obese subjects underwent magnetic resonance imaging and spectroscopy to measure liver size and fat content before and after intensive treatment with Optifast® VLCD for 6 weeks. Results: All subjects completing 6 weeks Optifast® VLCD lost weight. Body weight and BMI (median [interquartile range]) reduced from 119.7 [111.9-131.3] kg and 44 [40-51] kg/m2 respectively, to 110.6 [98.0- 124.5] kg and 40 [36-47] kg/m2, P<0.001. Median excess weight loss (EWL) was 15.1 [9.6-21.1]%. Baseline liver volume and fat content were related (r=0.633, P=0.005). After 6 weeks Optifast® VLCD, there was a 14.7% reduction in mean liver volume (P<0.001) and a 43% reduction in mean liver fat (P=0.016). The change in liver volume was predicted by the change in the liver fat (r = 0.610, P=0.012). Conclusion: This study has demonstrated that a 6- week diet with Optifast® VLCD results in significant related reductions in liver size and liver fat content. This suggests that the reduction in liver volume is due to loss of fat. The reduction in liver fat and volume likely accounts for the perceived improved operability in patients undergoing LAGB.
dc.description.statementofresponsibilityMark C. Lewis, Madeleine L. Phillips, John P. Slavotinek, Lilian Kow, Campbell H. Thompson and Jim Toouli
dc.identifier.citationObesity Surgery, 2006; 16(6):697-701
dc.identifier.doi10.1381/096089206777346682
dc.identifier.issn0960-8923
dc.identifier.issn1708-0428
dc.identifier.orcidThompson, C. [0000-0002-5164-3327]
dc.identifier.urihttp://hdl.handle.net/2440/66146
dc.language.isoen
dc.publisherF D-Communications Inc
dc.rights© FD-Communications Inc.
dc.source.urihttps://doi.org/10.1381/096089206777346682
dc.subjectLiver
dc.subjectAdipose Tissue
dc.subjectHumans
dc.subjectObesity, Morbid
dc.subjectMagnetic Resonance Imaging
dc.subjectLaparoscopy
dc.subjectOrgan Size
dc.subjectCaloric Restriction
dc.subjectGastroplasty
dc.subjectCross-Sectional Studies
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleChange in liver size and fat content after treatment with Optifast Very Low Calorie Diet
dc.typeJournal article
pubs.publication-statusPublished

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