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The 'Spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families

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dc.contributor.authorRoeper, K.
dc.contributor.authorGregory, S.
dc.contributor.authorBrown, N.
dc.date.issued2002
dc.description.abstractRecent studies have characterised a family of giant cytoskeletal crosslinkers encoded by the short stop gene in Drosophila and the dystonin/BPAG1 and MACF1 genes in mammals. We refer to the products of these genes as spectraplakins to highlight the fact that they share features with both the spectrin and plakin superfamilies. These genes produce a variety of large proteins, up to almost 9000 residues long, which can potentially extend 0.4 µm across a cell. Spectraplakins can interact with all three elements of the cytoskeleton: actin, microtubules and intermediate filaments. The analysis of mutant phenotypes in BPAG1 in mouse and short stop in Drosophila demonstrates that spectraplakins have diverse roles. These include linking the plasma membrane and the cytoskeleton, linking together different elements of the cytoskeleton and organising membrane domains.
dc.description.statementofresponsibilityKatja Röper, Stephen L. Gregory and Nicholas H. Brown
dc.identifier.citationJournal of Cell Science, 2002; 115(22):4215-4225
dc.identifier.doi10.1242/10.1242/jcs.00157
dc.identifier.issn0021-9533
dc.identifier.issn1477-9137
dc.identifier.orcidGregory, S. [0000-0002-0046-5815]
dc.identifier.urihttp://hdl.handle.net/2440/41876
dc.language.isoen
dc.publisherCompany of Biologists Ltd
dc.rightsCopyright © 2002 The Company of Biologists Ltd
dc.source.urihttps://doi.org/10.1242/jcs.00157
dc.subjectSpectrin
dc.subjectAdhesion
dc.subjectCytoskeleton
dc.subjectPlakin
dc.titleThe 'Spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families
dc.typeJournal article
pubs.publication-statusPublished

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