Lipogenic effects of androgen signaling in normal and malignant prostate

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dc.contributor.authorMah, C.Y.
dc.contributor.authorNassar, Z.D.
dc.contributor.authorSwinnen, J.V.
dc.contributor.authorButler, L.M.
dc.date.issued2020
dc.description.abstractProstate cancer is an androgen-dependent cancer with unique metabolic features compared to many other solid tumors, and typically does not exhibit the “Warburg effect”. During malignant transformation, an early metabolic switch diverts the dependence of normal prostate cells on aerobic glycolysis for the synthesis of and secretion of citrate towards a more energetically favorable metabolic phenotype, whereby citrate is actively oxidised for energy and biosynthetic processes (i.e. de novo lipogenesis). It is now clear that lipid metabolism is one of the key androgen-regulated processes in prostate cells and alterations in lipid metabolism are a hallmark of prostate cancer, whereby increased de novo lipogenesis accompanied by over expression of lipid metabolic genes are characteristic of primary and advanced disease. Despite recent advances in our understanding of altered lipid metabolism in prostate tumorigenesis and cancer progression, the intermediary metabolism of the normal prostate and its relationship to androgen signaling remains poorly understood. In this review, we discuss the fundamental metabolic relationships that are distinctive in normal versus malignant prostate tissues, and the role of androgens in the regulation of lipid metabolism at different stages of prostate tumorigenesis.
dc.description.statementofresponsibilityChui YanMah, Zeyad D.Nassar, Johannes V.Swinnen, Lisa M.Butler
dc.identifier.citationAsian Journal of Urology, 2020; 7(3):258-270
dc.identifier.doi10.1016/j.ajur.2019.12.003
dc.identifier.issn2214-3882
dc.identifier.issn2214-3890
dc.identifier.orcidMah, C.Y. [0000-0002-8820-4037]
dc.identifier.orcidNassar, Z.D. [0000-0002-7779-2697]
dc.identifier.orcidButler, L.M. [0000-0003-2698-3220]
dc.identifier.urihttps://hdl.handle.net/2440/133137
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/arc/130101004
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1138648
dc.rights© 2020 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. Thisis an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.source.urihttps://doi.org/10.1016/j.ajur.2019.12.003
dc.subjectAndrogen receptor; fatty acids; metabolism; phospholipids; prostate gland
dc.titleLipogenic effects of androgen signaling in normal and malignant prostate
dc.typeJournal article
pubs.publication-statusPublished

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