Oxygen-permeable microwell device maintains islet mass and integrity during shipping

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dc.contributor.authorRojas-Canales, D.
dc.contributor.authorWaibel, M.
dc.contributor.authorForget, A.
dc.contributor.authorPenko, D.
dc.contributor.authorNitschke, J.
dc.contributor.authorHarding, F.
dc.contributor.authorDelalat, B.
dc.contributor.authorBlencowe, A.
dc.contributor.authorLoudovaris, T.
dc.contributor.authorGrey, S.
dc.contributor.authorThomas, H.
dc.contributor.authorKay, T.
dc.contributor.authorDrogemuller, C.
dc.contributor.authorVoelcker, N.
dc.contributor.authorCoates, P.
dc.date.issued2018
dc.description.abstractIslet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islets are still lost in the pre-transplant period, limiting the success of this treatment. Moreover, current practice includes islets being prepared at specialized centers, which are sometimes remote to the transplant location. Thus, a critical point of intervention to maintain the quality and quantity of isolated islets is during transportation between isolation centers and the transplanting hospitals, during which 20-40% of functional islets can be lost. The current study investigated the use of an oxygen-permeable PDMS microwell device for long-distance transportation of isolated islets. We demonstrate that the microwell device protected islets from aggregation during transport, maintaining viability and average islet size during shipping.
dc.description.statementofresponsibilityDarling M Rojas-Canales, Michaela Waibel, Aurelien Forget, Daniella Penko, Jodie Nitschke, Fran J Harding, Bahman Delalat, Anton Blencowe, Thomas Loudovaris, Shane T Grey, Helen E Thomas, Thomas W H Kay, Chris J Drogemuller, Nicolas H Voelcker, and Patrick T Coates
dc.identifier.citationEndocrine Connections, 2018; 7(3):490-503
dc.identifier.doi10.1530/EC-17-0349
dc.identifier.issn2049-3614
dc.identifier.issn2049-3614
dc.identifier.orcidGrey, S. [0000-0003-2160-1625]
dc.identifier.orcidDrogemuller, C. [0000-0001-9770-4845]
dc.identifier.urihttp://hdl.handle.net/2440/118548
dc.language.isoen
dc.publisherBioScientifica
dc.rights© 2018 The authors 2018. Attribution 4.0 International (CC BY 4.0)
dc.source.urihttps://doi.org/10.1530/ec-17-0349
dc.subjecthypoxia
dc.subjectislet
dc.subjectmicrowell
dc.subjectshipping
dc.subjecttransplantation
dc.titleOxygen-permeable microwell device maintains islet mass and integrity during shipping
dc.typeJournal article
pubs.publication-statusPublished

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