Peri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer

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dc.contributor.authorNassar, Z.
dc.contributor.authorAref, A.
dc.contributor.authorMiladinovic, D.
dc.contributor.authorMah, C.
dc.contributor.authorRaj, G.
dc.contributor.authorHoy, A.
dc.contributor.authorButler, L.
dc.date.issued2018
dc.description.abstractEmerging data have linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta-analyses that have explored the associations between PCa and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that peri-prostatic adipose tissue (PPAT), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PCa pathogenesis and progression. Notably, several recent studies have identified secreted factors from both PPAT and PCa that potentially mediate the two-way communication between these intimately linked tissues. In the present review, we summarize the available literature regarding the relationship between PPAT and PCa, including the potential biological mediators of that relationship, and explore emerging areas of interest for future research endeavours.
dc.description.statementofresponsibilityZeyad D. Nassar, Adel T. Aref, Dushan Miladinovic, Chui Yan Mah, Ganesh V. Raj, Andrew J. Hoy and Lisa M. Butler
dc.identifier.citationBJU International, 2018; 121(Suppl. 3):9-21
dc.identifier.doi10.1111/bju.14173
dc.identifier.issn1464-4096
dc.identifier.issn1464-410X
dc.identifier.orcidNassar, Z. [0000-0002-7779-2697]
dc.identifier.orcidAref, A. [0000-0003-3028-131X]
dc.identifier.orcidMah, C. [0000-0002-8820-4037]
dc.identifier.orcidButler, L. [0000-0003-2698-3220]
dc.identifier.urihttp://hdl.handle.net/2440/112960
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1138648
dc.relation.granthttp://purl.org/au-research/grants/arc/FT130101004
dc.rights© 2018 The Authors. BJU International © 2018 BJU International. Published by John Wiley & Sons Ltd.
dc.source.urihttps://doi.org/10.1111/bju.14173
dc.subjectadipocytes
dc.subjectobesity
dc.subjectperi-prostatic adipose tissue
dc.subjectprostate cancer
dc.subjecttumour microenvironment
dc.titlePeri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer
dc.typeJournal article
pubs.publication-statusPublished

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