Serum relaxin in pregnancy

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dc.contributor.authorMaclennan, A.
dc.contributor.authorNicolson, R.
dc.contributor.authorGreen, R.
dc.date.issued1986
dc.description.abstractSerum relaxin immunoactivity was measured by means of a porcine radioimmunoassay in a cross-sectional study of 302 normal singleton pregnancies. Concentrations in the third trimester were lower than in early and mid pregnancy. At term, relaxin levels in patients who went into spontaneous labour within a week of sampling were significantly lower than in those who did not. However, relaxin levels were highest during labour and fell almost to non-pregnant levels by the third postnatal day. Levels in twin pregnancies in the third trimester were higher than those in singleton pregnancies. Serial samples from 4 patients with a history of premature labour showed declining, very low levels in the only patient who subsequently had a preterm delivery. These results are compatible with the proposed roles of relaxin during pregnancy: namely, to maintain myometrial quiescence, facilitate uterine stromal remodelling during uterine growth, and promote cervical ripening at the onset of parturition.
dc.description.statementofresponsibilityAlastair H. Maclennan, Ruth Nicolson, Roslyn C. Green
dc.identifier.citationThe Lancet, 1986; 328(8501):241-243
dc.identifier.doi10.1016/S0140-6736(86)92068-4
dc.identifier.issn0140-6736
dc.identifier.issn1474-547X
dc.identifier.urihttp://hdl.handle.net/2440/91459
dc.language.isoen
dc.publisherElsevier Science
dc.rightsCopyright © 1986 Published by Elsevier Ltd.
dc.source.urihttps://doi.org/10.1016/s0140-6736(86)92068-4
dc.subjectHumans
dc.subjectRelaxin
dc.subjectRadioimmunoassay
dc.subjectPostpartum Period
dc.subjectPregnancy
dc.subjectLabor, Obstetric
dc.subjectPregnancy, Multiple
dc.subjectPregnancy Trimester, Third
dc.subjectFemale
dc.subjectObstetric Labor, Premature
dc.titleSerum relaxin in pregnancy
dc.typeJournal article
pubs.publication-statusPublished

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