Leisureātime physical activity and life expectancy in people with cardiometabolic multimorbidity and depression
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(Published version)
Date
2020
Authors
Chudasama, Y.V.
Zaccardi, F.
Gillies, C.L.
Dhalwani, N.N.
Yates, T.
Rowlands, A.V.
Davies, M.J.
Khunto, K.K.
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Journal article
Citation
Journal of Internal Medicine, 2020; 287(1):87-99
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Abstract
Background: Whether and to what extent leisureātime physical activity at the recommended levels of 150 minutes moderate activity is associated with survival in people with cardiometabolic multimorbidity and depression is unknown.
Methods: UK Biobank participants were classified into groups: (1) no disease; (2) diabetes; (3) cardiovascular disease (CVD); (4) depression; (5) diabetes and CVD; (6) diabetes and depression; (7) CVD and depression; (8) diabetes, CVD and depression. Leisureātime physical activity was categorised as active (meeting recommendations) or inactive. Survival models were applied to estimate life expectancy.
Results: 480,940 participants were included (median age, 58 years; 46% men; 95% white), of whom 74% with cardiometabolic multimorbidity and depression were inactive. During a mean followāup of 7 years, 11006 deaths occurred. At age of 45 years, being physically active was associated with 2.34 (95% confidence interval: 0.93, 3.54) additional years of life compared to being inactive in participants with diabetes; corresponding estimate were 2.28 (1.40, 3.16) for CVD; 2.15 (0.05, 4.26) for diabetes and CVD; and 1.58 (1.27, 1.89) for no disease. Participants with a combination of diabetes, CVD and depression, being active was associated with 6.81 (ā1.50, 15.31) additional years compared to being inactive; corresponding estimates were 3.07 (ā2.46, 8.59) for diabetes and depression; 2.34 (ā1.24, 5.91) for CVD and depression; and 0.80 (ā0.46, 2.05) for depression. A similar pattern was found at 65 years.
Conclusions: Meeting the recommended level of physical activity was associated with a longer life expectancy in people with cardiometabolic multimorbidity but not in those with depression.
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Data source: Yes, https://www.ukbiobank.ac.uk
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Copyright 2019 The Association for the Publication of the Journal of Internal Medicine
Access Condition Notes: Accepted manuscript available after 1 January 2021