Enantioselective synthesis of α-fluorinated β²-amino acids

Date

2008

Authors

Edmonds, M.
Graichen, F.
Gardiner, J.
Abell, A.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Organic Letters, 2008; 10(5):885-887

Statement of Responsibility

Michael K. Edmonds, Florian H. M. Graichen, James Gardiner, and Andrew D. Abell

Conference Name

Abstract

A methodology for the enantioselective synthesis of α-fluorinated β²-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β²-amino acids.

School/Discipline

Dissertation Note

Provenance

Web Release Date: January 31, 2008

Description

Copyright © 2008 American Chemical Society

Access Status

Rights

License

Grant ID

Call number

Persistent link to this record