Enantioselective synthesis of α-fluorinated β²-amino acids
Date
2008
Authors
Edmonds, M.
Graichen, F.
Gardiner, J.
Abell, A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Organic Letters, 2008; 10(5):885-887
Statement of Responsibility
Michael K. Edmonds, Florian H. M. Graichen, James Gardiner, and Andrew D. Abell
Conference Name
Abstract
A methodology for the enantioselective synthesis of α-fluorinated β²-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β²-amino acids.
School/Discipline
Dissertation Note
Provenance
Web Release Date: January 31, 2008
Description
Copyright © 2008 American Chemical Society