Dysregulated innate immune function in the aetiopathogenesis of idiopathic inflammatory myopathies

Simple item page
dc.contributor.authorDay, J.
dc.contributor.authorOtto, S.
dc.contributor.authorProudman, S.
dc.contributor.authorHayball, J.D.
dc.contributor.authorLimaye, V.
dc.date.issued2017
dc.description.abstractThe idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic muscle conditions that are believed to be autoimmune in nature. They have distinct pathological features, but the aetiopathogenesis of each subtype remains largely unknown. Recently, there has been increased interest in the complex role the innate immune system plays in initiating and perpetuating these conditions, and how this may differ between subtypes. This article summarises the traditional paradigms of IIM pathogenesis and reviews the accumulating evidence for disturbances in innate immune processes in these rare, but debilitating chronic conditions.
dc.description.statementofresponsibilityJessica Day, Sophia Otto, Susanna Proudman, John D.Hayball, Vidya Limaye
dc.identifier.citationAutoimmunity Reviews, 2017; 16(1):87-95
dc.identifier.doi10.1016/j.autrev.2016.09.019
dc.identifier.issn1568-9972
dc.identifier.issn1873-0183
dc.identifier.orcidProudman, S. [0000-0002-3046-9884]
dc.identifier.orcidHayball, J.D. [0000-0002-3089-4506]
dc.identifier.orcidLimaye, V. [0000-0002-8142-9532]
dc.identifier.urihttps://hdl.handle.net/2440/132786
dc.language.isoen
dc.publisherElsevier
dc.relation.grantNHMRC
dc.rights© 2016 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.autrev.2016.09.019
dc.subjectMuscle, Skeletal
dc.subjectMacrophages
dc.subjectImmune System
dc.subjectAnimals
dc.subjectHumans
dc.subjectMyositis
dc.subjectChemokines
dc.subjectGene Expression Regulation
dc.subjectImmunity, Innate
dc.subject.meshMuscle, Skeletal
dc.subject.meshMacrophages
dc.subject.meshImmune System
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshMyositis
dc.subject.meshChemokines
dc.subject.meshGene Expression Regulation
dc.subject.meshImmunity, Innate
dc.titleDysregulated innate immune function in the aetiopathogenesis of idiopathic inflammatory myopathies
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications