Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking

Simple item page
dc.contributor.authorGong, P.
dc.contributor.authorMcLaughlin, R.
dc.contributor.authorLiew, Y.
dc.contributor.authorMunro, P.
dc.contributor.authorWood, F.
dc.contributor.authorSampson, D.
dc.date.issued2014
dc.description.abstractThe formation of burn-scar tissue in human skin profoundly alters, among other things, the structure of the dermis. We present a method to characterize dermal scar tissue by the measurement of the near-infrared attenuation coefficient using optical coherence tomography (OCT). To generate accurate en face parametric images of attenuation, we found it critical to first identify (using speckle decorrelation) and mask the tissue vasculature from the three-dimensional OCT data. The resulting attenuation coefficients in the vasculature-masked regions of the dermis of human burn-scar patients are lower in hypertrophic (3.8±0.4  mm(-1)) and normotrophic (4.2±0.9  mm(-1)) scars than in contralateral or adjacent normal skin (6.3±0.5  mm(-1)). Our results suggest that the attenuation coefficient of vasculature-masked tissue could be used as an objective means to assess human burn scars.
dc.description.statementofresponsibilityPeijun Gong, Robert A. McLaughlin, Yih Miin Liew, Peter R. T. Munro, Fiona M. Wood, David D. Sampson
dc.identifier.citationJournal of Biomedical Optics, 2014; 19(2):21111-21111
dc.identifier.doi10.1117/1.JBO.19.2.021111
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.orcidMcLaughlin, R. [0000-0001-6947-5061]
dc.identifier.urihttp://hdl.handle.net/2440/106199
dc.language.isoen
dc.publisherSociety of Photo-Optical Instrumentation Engineers
dc.relation.granthttp://purl.org/au-research/grants/arc/DE120101331
dc.rights© 2014 Society of Photo-Optical Instrumentation Engineers
dc.source.urihttps://doi.org/10.1117/1.jbo.19.2.021111
dc.subjectImage Processing, Computer-Assisted
dc.titleAssessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Physics publications