Quality of life assessment in esophageal atresia patients: a systematic review focusing on long-gap esophageal atresia

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dc.contributor.authorTan Tanny, S.P.
dc.contributor.authorComella, A.
dc.contributor.authorHutson, J.M.
dc.contributor.authorOmari, T.I.
dc.contributor.authorTeague, W.J.
dc.contributor.authorKing, S.K.
dc.date.issued2019
dc.description.abstractBackground: Children born with esophageal atresia (EA) have inherent abnormalities in esophageal motility which may impact upon patient and family Quality of Life (QoL). Currently, paucity of data exists for long-term outcomes of long-gap EA. We aimed to: (1) summarize QoL tools reported in the literature, focusing upon studies involving long-gap EA patients, and (2) compare QoL for long-gap versus non-long-gap EA patients. Method: We performed a systematic review of Cochrane Register of Controlled Trials, PubMed, EMBASE, and Ovid databases (January 1980-May 2018) in accordance with the PRISMA protocol. Result: Six studies were identified (536 patients total), and 419/536 (78%) patients completed QoL assessment. Response rates ranged from 29% to 100%. Median study size was 86 (range 8-159). Esophageal atresia type was described in 477 patients, and 74/477 (16%) were long-gap. Common assessment tools were Gastrointestinal Quality of Life Index and 36-Item Short-Form Health Survey. Compared with healthy individuals, long-gap EA patients suffered more gastrointestinal symptoms. There were no significant differences in QoL outcomes between long-gap and non-long-gap EA patients. Conclusion: Current literature suggests no significant difference in QoL outcomes between long-gap and non-long-gap EA patients. However, due to questionnaire variability and range of response rates, the data should be interpreted with care. Level of Evidence: Level II.
dc.description.statementofresponsibilitySharman P. Tan Tanny, Assia Comella, John M. Hutson, Taher I. Omari, Warwick J. Teague, Sebastian K. King
dc.identifier.citationJournal of Pediatric Surgery, 2019; 54(12):2473-2478
dc.identifier.doi10.1016/j.jpedsurg.2019.08.040
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.orcidOmari, T.I. [0000-0001-5108-7378]
dc.identifier.orcidTeague, W.J. [0000-0003-4747-6025]
dc.identifier.urihttp://hdl.handle.net/2440/124250
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1168142
dc.rightsCrown Copyright © 2019 Published by Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.jpedsurg.2019.08.040
dc.subjectEsophageal atresia; long-gap; quality of life; systematic review
dc.titleQuality of life assessment in esophageal atresia patients: a systematic review focusing on long-gap esophageal atresia
dc.typeJournal article
pubs.publication-statusPublished

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