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Guidelines and definitions for research on epithelial-mesenchymal transition

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dc.contributor.authorYang, J.
dc.contributor.authorAntin, P.
dc.contributor.authorBerx, G.
dc.contributor.authorBlanpain, C.
dc.contributor.authorGoodall, G.J.
dc.contributor.authorKhew Goodall, Y.
dc.contributor.authorSheng, G.
dc.date.issued2020
dc.descriptionData source: Supplementary information, https://doi.org/10.1038/s41580-020-0237-9 Link to a related website: https://doi.org/10.1038/s41580-021-00428-9, Author Correction
dc.description.abstractEpithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMTis expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
dc.identifier.citationNature Reviews Molecular Cell Biology, 2020; 21(6):341-352
dc.identifier.doi10.1038/s41580-020-0237-9
dc.identifier.issn1471-0072
dc.identifier.issn1471-0080
dc.identifier.orcidGoodall, G.J. [0000-0003-1294-0692]
dc.identifier.urihttps://hdl.handle.net/11541.2/142409
dc.language.isoen
dc.publisherNature
dc.rightsCopyright 2020 The Author(s) This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use,sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1038/s41580-020-0237-9
dc.subjectepithelial–mesenchymal transition (EMT)
dc.subjectcell migration
dc.subjectEMT International Association (TEMTIA)
dc.titleGuidelines and definitions for research on epithelial-mesenchymal transition
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12220066730001831 13220076710001831 s41580-020-0237-9.pdf
ror.mmsid9916398606301831

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