Discordant effects of vitamin D deficiency in trabecular and cortical bone architecture and strength in growing rodents
Date
2010
Authors
Lee, A.
Anderson, P.
Sawyer, R.
Moore, A.
Forwood, M.
Steck, R.
Morris, H.
O'Loughlin, P.
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Journal article
Citation
Journal of Steroid Biochemistry and Molecular Biology, 2010; 121(1-2):284-287
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Alice M.C. Lee, Paul H. Anderson, Rebecca K. Sawyer, Alison J. Moore, Mark R. Forwood, Roland Steck, Howard A. Morris and Peter D. O’Loughlin
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Abstract
We have previously shown that vitamin D deficiency in young male rats results in significant reduction in femoral trabecular bone volume (BV/TV). However, the effects of vitamin D deficiency and its impact on other relevant skeletal sites remain unclear. Ten week old male Sprague-Dawley rats were fed various levels of vitamin D3 (2, 4, 8, and 12 IU/day) with standard Ca (0.4%) until 30 weeks of age and achieved stable serum 25-hydroxyvitamin D3 (25D) levels between 16 and 117 nmol/L. At time of death, femora, L2 vertebrae and tibiae were processed for bone histomorphometric analyses and tibial cortical strength by 3-point mechanical testing. A significant association between serum 25D and trabecular bone occurred for both the distal femoral metaphysis (R2 = 0.34, P < 0.05) and L2 vertebrae (R2 = 0.24, P < 0.05). Tibia mid-shaft cortical bone was not, however, changed in terms of total volume, periosteal surface or endosteal surface as a function of vitamin D status. Furthermore, no changes to mechanical and intrinsic properties of the cortices were observed. We conclude that cortical bone is maintained under conditions of vitamin D deficiency in preference to cancellous bone in young growing rats.
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© 2010 Published by Elsevier Ltd.