Localised astroglial dysfunction disrupts high-frequency EEG rhythms

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dc.contributor.authorWilloughby, J.
dc.contributor.authorMackenzie, L.
dc.contributor.authorPope, K.
dc.contributor.authorBroberg, M.
dc.contributor.authorNilsson, M.
dc.date.issued2005
dc.description.abstractWe used cerebral cortex injections of fluorocitrate to determine if selective astrocytic disturbances affect the electroencephalogram (EEG). Rats were halothane-anaesthetized and 0.8nmol of sodium fluorocitrate was injected into hindlimb (motor-sensory) cortex. Extra-dural EEG electrodes were implanted after which the anaesthesia was ceased. EEG was recorded at 1, 3, 5, 7, 24 and 48 hours. There was a broad-band reduction in frequencies in the EEG between 20 and 100Hz commencing within 1 hour of injection and largely restricted to the side of injection and to frontal cortex, and maximal at 3 hours. Halothane had a suppressive effect on gamma power after citrate injection, but also prevented EEG suppression caused by fluorocitrate, consistent with the hypothesis that some of the action of fluorocitrate depended on gap-junctions. The findings are consistent with the hypothesis that primary astroglial dysfunction leads to reduced neuronal transmission and further supports gap-junctions as mediating fluorocitrate-induced astroglial effects.
dc.description.statementofresponsibilityJ. O. Willoughby, L. Mackenzie, K. J. Pope, M. Broberg, and M. Nilsson
dc.identifier.citationJournal of Neural Transmission, 2005; 112(2):205-213
dc.identifier.doi10.1007/s00702-004-0189-9
dc.identifier.issn0300-9564
dc.identifier.issn1435-1463
dc.identifier.urihttp://hdl.handle.net/2440/38917
dc.language.isoen
dc.publisherSpringer-Verlag Wien
dc.source.urihttps://doi.org/10.1007/s00702-004-0189-9
dc.subjectdelta
dc.subjectbeta
dc.subjectgamma
dc.subjectEEG
dc.subjectpower spectrum
dc.subjectgap-junctions
dc.titleLocalised astroglial dysfunction disrupts high-frequency EEG rhythms
dc.typeJournal article
pubs.publication-statusPublished

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