Umbilical cord blood testosterone and childhood internalizing and externalizing behavior: a prospective study

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dc.contributor.authorRobinson, M.
dc.contributor.authorWhitehouse, A.
dc.contributor.authorJacoby, P.
dc.contributor.authorMattes, E.
dc.contributor.authorSawyer, M.
dc.contributor.authorKeelan, J.
dc.contributor.authorHickey, M.
dc.contributor.editorSchooling, C.M.
dc.date.issued2013
dc.descriptionExtent: 8 p.
dc.description.abstractAntenatal testosterone exposure influences fetal neurodevelopment and gender-role behavior in postnatal life and may contribute to differences in developmental psychopathology during childhood. We prospectively measured the associations between umbilical cord blood testosterone levels at birth and childhood behavioral development in both males and females from a large population based sample. The study comprised 430 females and 429 males from the Western Australian Pregnancy Cohort (Raine) Study where umbilical cord blood had been collected. Total testosterone concentrations were determined by mass spectrometry and bioavailable testosterone (BioT) levels were calculated. At two, five, eight and ten years of age, the participants completed the Child Behavior Checklist (CBCL). Linear regression models were used to analyse the relationship between BioT concentrations (in quartiles) and CBCL scores (total, internalizing, externalizing and selected syndrome). Boys had higher mean CBCL T-scores than girls across all ages of follow-up. There was no significant relationship between cord blood BioT quartiles and CBCL total, internalizing and externalizing T-scores at age two or five to ten combined. In the syndrome score analyses, higher BioT quartiles were associated with significantly lower scores for attention problems for boys at age five, eight and ten, and greater withdrawal symptoms in pre-school girls (age five). We did not identify a consistent relationship between antenatal testosterone exposure and total, internalizing or externalizing behavioral difficulties in childhood. Higher umbilical cord BioT levels were associated with lower scores for attention problems in boys up to 10 years and more withdrawn behavior in 5-year-old girls; however, these findings were not consistent across ages and require further investigation in a larger sample.
dc.description.statementofresponsibilityMonique Robinson, Andrew J.O. Whitehouse, Peter Jacoby, Eugen Mattes, Michael G. Sawyer, Jeffrey A. Keelan and Martha Hickey
dc.identifier.citationPLoS One, 2013; 8(4):1-8
dc.identifier.doi10.1371/journal.pone.0059991
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidSawyer, M. [0000-0002-7834-0561]
dc.identifier.urihttp://hdl.handle.net/2440/79584
dc.language.isoen
dc.publisherPublic Library of Science
dc.rightsCopyright: © 2013 Robinson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0059991
dc.subjectFetal Blood
dc.subjectHumans
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectTestosterone
dc.subjectLinear Models
dc.subjectCohort Studies
dc.subjectProspective Studies
dc.subjectChild Behavior Disorders
dc.subjectPregnancy
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.titleUmbilical cord blood testosterone and childhood internalizing and externalizing behavior: a prospective study
dc.typeJournal article
pubs.publication-statusPublished

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