5-ASA decreases colonic sulfide formation: implications for ulcerative colitis.
| dc.contributor.author | Roediger, W. | |
| dc.contributor.author | Duncan, A. | |
| dc.date.issued | 1996 | |
| dc.description.abstract | Experimental evidence suggests that anionic sulfide (SH-) may be implicated in the pathogenesis of ulcerative colitis. Sulfides are formed in the colon by sulfate-reducing bacteria acting on sulfate or sulfur amino acids. Experiments were designed to test whether the most useful drug for ulcerative colitis, 5-aminosalicylic acid (5ASA) or salicylazosulfapyridine (SASP) could suppress sulfide formation from sulfur amino acids by anaerobic bacteria grown in batch culture. Neither 5-ASA or SASP altered acetate formation, a universal indicator of fermentation. Both agents very significantly reduced sulfide formation by anaerobic bacteria of the human colon grown in batch culture. Such an action of 5-ASA/SASP may reduce the injurious action of sulfide on the colonie epithelial cell barrier of the colon and help to prevent attacks of colitis. Keywords: 5-aminosalicylic acid, colon, sulfides, ulcerative colitis, fermentation. | |
| dc.identifier.citation | Medical science research, 1996; 24(1):27-29 | |
| dc.identifier.issn | 0269-8951 | |
| dc.identifier.orcid | Roediger, W. [0000-0002-6480-4804] | |
| dc.identifier.uri | http://hdl.handle.net/2440/10211 | |
| dc.language.iso | en | |
| dc.title | 5-ASA decreases colonic sulfide formation: implications for ulcerative colitis. | |
| dc.type | Journal article | |
| pubs.publication-status | Published |