The role of activins and follistatins in skin and hair follicle development and function

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dc.contributor.authorMcDowall, M.
dc.contributor.authorEdwards, N.
dc.contributor.authorJahoda, C.
dc.contributor.authorHynd, P.
dc.date.issued2008
dc.description.abstractInvestigations of the signalling between epithelial and mesenchymal compartments of skin during hair follicle initiation in utero and hair cycling have revealed the importance of the TGFbeta superfamily in ectodermal organogenesis and morphogenesis. In particular the activins, their receptors and binding proteins such as follistatin, have been shown to be important regulators of cell proliferation, differentiation and apoptosis in hair follicle initiation, hair cycling, normal skin homeostasis and wound healing. Transgenic mice lacking various components of the activin signalling pathways display varying ectodermal pathologies including altered pelage hair follicle initiation. This review summarises the activin signal transduction pathways and the interactions between activins and other TGFbeta signalling systems during hair follicle formation, hair growth cycling, skin function and wound healing.
dc.description.statementofresponsibilityM. McDowall, N.M. Edwards, C.A.B. Jahoda and P.I. Hynd
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#description
dc.identifier.citationCytokine and Growth Factor Reviews, 2008; 19(5-6):415-426
dc.identifier.doi10.1016/j.cytogfr.2008.08.005
dc.identifier.issn1359-6101
dc.identifier.issn1879-0305
dc.identifier.orcidMcDowall, M. [0000-0002-4121-0202]
dc.identifier.orcidHynd, P. [0000-0001-6123-8037]
dc.identifier.urihttp://hdl.handle.net/2440/51548
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.source.urihttps://doi.org/10.1016/j.cytogfr.2008.08.005
dc.subjectHair Follicle
dc.subjectSkin
dc.subjectAnimals
dc.subjectMice, Transgenic
dc.subjectMice
dc.subjectActivins
dc.subjectActivin Receptors
dc.subjectTransforming Growth Factor beta
dc.subjectFollistatin
dc.subjectWound Healing
dc.subjectSignal Transduction
dc.titleThe role of activins and follistatins in skin and hair follicle development and function
dc.typeJournal article
pubs.publication-statusPublished

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