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Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression

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dc.contributor.authorKolesnikoff, N.
dc.contributor.authorChen, C.-H.
dc.contributor.authorSamuel, M.S.
dc.date.issued2022
dc.description.abstractSolid tumours are composed of cancer cells characterised by genetic mutations that underpin the disease, but also contain a suite of genetically normal cells and the extracellular matrix (ECM). These two latter components are constituents of the tumour microenvironment (TME), and are key determinants of tumour biology and thereby the outcomes for patients. The tumour ECM has been the subject of intense research over the past two decades, revealing key biochemical and mechanobiological principles that underpin its role in tumour cell proliferation and survival. However, the ECM also strongly influences the genetically normal immune cells within the microenvironment, regulating not only their proliferation and survival, but also their differentiation and access to tumour cells. Here we review recent advances in our knowledge of how the ECM regulates the tumour immune microenvironment and vice versa, comparing normal skin wound healing to the pathological condition of tumour progression.
dc.description.statementofresponsibilityNatasha Kolesnikoff, Chun-Hsien Chen, and Michael Susithiran Samuel
dc.identifier.citationClinical Science, 2022; 136(5):361-377
dc.identifier.doi10.1042/cs20210679
dc.identifier.issn0143-5221
dc.identifier.issn1470-8736
dc.identifier.orcidKolesnikoff, N. [0000-0003-4314-4779]
dc.identifier.orcidSamuel, M.S. [0000-0001-7880-6379]
dc.identifier.urihttps://hdl.handle.net/2440/135072
dc.language.isoen
dc.publisherPortland Press Ltd.
dc.relation.granthttp://purl.org/au-research/grants/arc/FT120100132
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1103712
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1145319
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1184809
dc.rights© 2022 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
dc.source.urihttps://doi.org/10.1042/CS20210679
dc.subjectextracellular matrix
dc.subjectinfiltration
dc.subjectstroma
dc.subjecttumour immunity
dc.subjectwound healing
dc.titleInterrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression
dc.typeJournal article
pubs.publication-statusPublished

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