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Early pregnancy cardio metabolic risk factors and the prevalence of metabolic syndrome 10 years after the first pregnancy

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dc.contributor.authorAndraweera, P.H.
dc.contributor.authorPlummer, M.D.
dc.contributor.authorGarrett, A.
dc.contributor.authorLeemaqz, S.
dc.contributor.authorWittwer, M.R.
dc.contributor.authorAldridge, E.
dc.contributor.authorPathirana, M.M.
dc.contributor.authorDekker, G.A.
dc.contributor.authorRoberts, C.T.
dc.contributor.authorArstall, M.A.
dc.contributor.editorNgene, N.C.
dc.date.issued2023
dc.description.abstractBackground We aimed to compare risk factors for CVD 10 years postpartum among women who had ≥ 1 compared to no cardio metabolic risk factor in early first pregnancy. Methods Women of the SCOPE (Screening fOr Pregnancy Endpoints) study from Adelaide, South Australia were invited to participate in a cardiovascular risk assessment 10 years after the delivery of the first child. Data from 141 women who completed all the assessments are included in the analyses. Result Compared to women who did not have any cardio metabolic risk factor at 15 ± 1 weeks’ gestation during the first pregnancy, those who had ≥ 1 risk factor were 5.5 times more likely to have metabolic syndrome 10 years postpartum (aOR = 5.5, 95% CI 1.8–17.3, p = 0.004). Women who had ≥ 1cardio metabolic risk factor during the first pregnancy were more likely to be obese (p = 0.001), have high total cholesterol levels (p <0.001) or have increased insulin resistance (p <0.001) 10 years later compared to women who had no risk factor during the first pregnancy. 63.5% of the women with no cardio metabolic risk factor compared to 39% of women who had ≥ 1 risk factor in first pregnancy, had neither a complicated first pregnancy nor was diagnosed with MetS 10 years postpartum (p = 0.023). Conclusion Cardio metabolic risk factors at the booking visit in the first pregnancy may be useful in identifying young women at risk of future CVD.
dc.description.statementofresponsibilityPrabha H. Andraweera, Michelle D. Plummer, Amy Garrett, Shalem Leemaqz, Melanie R. Wittwer, Emily Aldridge, Maleesa M. Pathirana, Gus A. Dekker, Claire T. Roberts, Margaret A. Arstall
dc.identifier.citationPLoS ONE, 2023; 18(1):1-11
dc.identifier.doi10.1371/journal.pone.0280451
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidAndraweera, P.H. [0000-0003-2434-8370]
dc.identifier.orcidGarrett, A. [0000-0002-8410-0556]
dc.identifier.orcidLeemaqz, S. [0000-0003-4616-8426]
dc.identifier.orcidWittwer, M.R. [0000-0002-2551-3246]
dc.identifier.orcidAldridge, E. [0000-0001-5029-3946]
dc.identifier.orcidPathirana, M.M. [0000-0002-5817-4156]
dc.identifier.orcidDekker, G.A. [0000-0002-7362-6683]
dc.identifier.orcidRoberts, C.T. [0000-0002-9250-2192]
dc.identifier.orcidArstall, M.A. [0000-0003-0760-6382]
dc.identifier.urihttps://hdl.handle.net/2440/138135
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1090778
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1174971
dc.rights© 2023 Andraweera et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0280451
dc.subjectHumans
dc.subjectPregnancy Complications
dc.subjectCardiovascular Diseases
dc.subjectObesity
dc.subjectPrevalence
dc.subjectRisk Factors
dc.subjectPregnancy
dc.subjectFemale
dc.subjectMetabolic Syndrome
dc.subject.meshHumans
dc.subject.meshPregnancy Complications
dc.subject.meshCardiovascular Diseases
dc.subject.meshObesity
dc.subject.meshPrevalence
dc.subject.meshRisk Factors
dc.subject.meshPregnancy
dc.subject.meshFemale
dc.subject.meshMetabolic Syndrome
dc.titleEarly pregnancy cardio metabolic risk factors and the prevalence of metabolic syndrome 10 years after the first pregnancy
dc.typeJournal article
pubs.publication-statusPublished

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