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Bioceramics composition modulate resorption of human osteoclasts

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dc.contributor.authorRamaswamy, Y.
dc.contributor.authorHaynes, D.
dc.contributor.authorBerger, G.
dc.contributor.authorGildenhaar, R.
dc.contributor.authorLucas, H.
dc.contributor.authorHolding, C.
dc.contributor.authorZreiqat, H.
dc.date.issued2005
dc.description.abstractBiomaterials used in bone regeneration are designed to be gradually resorbed by the osteoclast and replaced by new bone formed through osteoblastic activity. The aim of the present study is to analyze the role of osteoclasts in the resorption process. The attachment of human osteoclasts and the appearance of their resorption lacunae, when cultured on either the resorbable crystalline, calcium orthophosphate materials or on the long-term stable bioceramic material was investigated. The resorbable materials contain Ca10[K,Na](PO4)7 (AW-Si) and Ca2KNa(PO4)2 (GB14, GB9 & D9/25) as their main crystal phases, however they differ in their total solubility. These differences result from small variations in the composition. The long-term stable material consist of about 30% fluorapatite beside calcium zirconium phosphate (Ca5(PO4)3F + CaZr4(PO4)6) and shows a very small solubility. AW-Si has an alkali containing crystalline phase, Ca10[K,Na](PO4). While GB14, GB9 and D9/25 contain the crystalline phase Ca2KNa(PO4)2 with small additions of crystalline and amorphous diphosphates and/or magnesium potassium phosphate (GB14). D9/25 and AW-Si is less soluble compared to GB14, and GB9 among the resorbable materials. Resorbable and long-term stable materials vary in their chemical compositions, solubility, and surface morphology. Osteoclasts modified the surface in their attempts to resorb the materials irrespective of the differences in their physical and chemical properties. The depth and morphology of the resorption imprints were different depending on the type of material. These changes in the surface structure created by osteoclasts are likely to affect the way osteoblasts interact with the materials and how bone is subsequently formed.
dc.description.statementofresponsibilityY. Ramaswamy, D. R. Haynes, G. Berger, R. Gildenhaar, H. Lucas, C. Holding and H. Zreiqat
dc.identifier.citationJournal of Materials Science: Materials in Medicine, 2005; 16(12):1199-1205
dc.identifier.doi10.1007/s10856-005-4729-0
dc.identifier.issn0957-4530
dc.identifier.issn1573-4838
dc.identifier.urihttp://hdl.handle.net/2440/17161
dc.language.isoen
dc.publisherKluwer Academic Publ
dc.rights© Springer
dc.source.urihttps://doi.org/10.1007/s10856-005-4729-0
dc.subjectOsteoclasts
dc.subjectHumans
dc.subjectBone Resorption
dc.subjectBiocompatible Materials
dc.subjectCeramics
dc.subjectMicroscopy, Electron, Scanning
dc.subjectSolubility
dc.titleBioceramics composition modulate resorption of human osteoclasts
dc.typeJournal article
pubs.publication-statusPublished

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