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Biosynthesis of uridine diphosphate N-Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?

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dc.contributor.authorWyllie, J.A.
dc.contributor.authorMcKay, M.V.
dc.contributor.authorBarrow, A.S.
dc.contributor.authorSoares da Costa, T.P.
dc.date.issued2022
dc.descriptionPublished December 2022
dc.description.abstractAlthough the prevalence of antibiotic resistance is increasing at an alarmingrate, there are a dwindling number of effective antibiotics available. Thus, the development of novel antibacterial agents should be of utmost importance.Peptidoglycan biosynthesis has been and is still an attractive source for antibi-otic targets; however, there are several components that remain underex-ploited. In this review, we examine the enzymes involved in the biosynthesis of one such component, UDP-N-acetylglucosamine, an essential building block and precursor of bacterial peptidoglycan. Furthermore, given the presence of a similar biosynthesis pathway in eukaryotes, we discuss the current knowledge on the differences and similarities between the bacterial and eukaryoticenzymes. Finally, this review also summarises the recent advances made in the development of inhibitors targeting the bacterial enzymes.
dc.description.statementofresponsibilityJessica A. Wyllie, Mirrin V. McKay, Andrew S. Barrow, Tatiana P. Soares da Costa
dc.identifier.citationIUBMB Life, 2022; 71(12):1232-1252
dc.identifier.doi10.1002/iub.2664
dc.identifier.issn1521-6543
dc.identifier.issn1521-6551
dc.identifier.orcidMcKay, M.V. [0000-0003-2242-1917]
dc.identifier.orcidBarrow, A.S. [0000-0003-3661-5173]
dc.identifier.orcidSoares da Costa, T.P. [0000-0002-6275-7485]
dc.identifier.urihttps://hdl.handle.net/2440/136015
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/arc/DP220101901
dc.relation.granthttp://purl.org/au-research/grants/arc/DE19100806
dc.rights© 2022 The Authors.IUBMB Life published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology.This is an open access article under the terms of theCreative Commons Attribution-NonCommercialLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.source.urihttps://doi.org/10.1002/iub.2664
dc.subjectantibiotic resistance; bifunctional GlmU; glucosamine-6-phosphate synthase; peptidoglycan biosynthesis; phosphoglucosamine mutase; UDP-N-acetylglucosamine biosynthesis
dc.titleBiosynthesis of uridine diphosphate N-Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?
dc.typeJournal article
pubs.publication-statusPublished

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