Cancer-cell-specific nuclear-targeted drug delivery by dual-ligand-modified mesoporous silica nanoparticles
Date
2015
Authors
Xiong, L.
Du, X.
Kleitz, F.
Qiao, S.
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Journal article
Citation
Small, 2015; 11(44):5919-5926
Statement of Responsibility
Lin Xiong, Xin Du, Freddy Kleitz and Shi Zhang Qiao
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Abstract
Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active nucleus accumulation but also reduce toxic side effects on noncancer cells though receptor-mediated selective cellular uptake.
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© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim