Occupational and environmental risk factors for idiopathic pulmonary fibrosis in Australia: case-control study

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dc.contributor.authorAbramson, M.J.
dc.contributor.authorMurambadoro, T.
dc.contributor.authorAlif, S.M.
dc.contributor.authorBenke, G.P.
dc.contributor.authorDharmage, S.C.
dc.contributor.authorGlaspole, I.
dc.contributor.authorHopkins, P.
dc.contributor.authorHoy, R.F.
dc.contributor.authorKlebe, S.
dc.contributor.authorMoodley, Y.
dc.contributor.authorRawson, S.
dc.contributor.authorReynolds, P.N.
dc.contributor.authorWolfe, R.
dc.contributor.authorCorte, T.J.
dc.contributor.authorWalters, E.H.
dc.date.issued2020
dc.description.abstractIntroduction Idiopathic pulmonary fibrosis (IPF) is a lung disease of unknown cause characterised by progressive scarring, with limited effective treatment and a median survival of only 2–3 years. Our aim was to identify potential occupational and environmental exposures associated with IPF in Australia. Methods Cases were recruited by the Australian IPF registry. Population-based controls were recruited by random digit dialling, frequency matched on age, sex and state. Participants completed a questionnaire on demographics, smoking, family history, environmental and occupational exposures. Occupational exposure assessment was undertaken with the Finnish Job Exposure Matrix and Australian asbestos JEM. Multivariable logistic regression was used to describe associations with IPF as ORs and 95% CIs, adjusted for age, sex, state and smoking. Results We recruited 503 cases (mean±SD age 71±9 years, 69% male) and 902 controls (71±8 years, 69% male). Ever smoking tobacco was associated with increased risk of IPF: OR 2.20 (95% CI 1.74 to 2.79), but ever using marijuana with reduced risk after adjusting for tobacco: 0.51 (0.33 to 0.78). A family history of pulmonary fibrosis was associated with 12.6-fold (6.52 to 24.2) increased risk of IPF. Occupational exposures to secondhand smoke (OR 2.1; 1.2 to 3.7), respirable dust (OR 1.38; 1.04 to 1.82) and asbestos (OR 1.57; 1.15 to 2.15) were independently associated with increased risk of IPF. However occupational exposures to other specific organic, mineral or metal dusts were not associated with IPF. Conclusion The burden of IPF could be reduced by intensified tobacco control, occupational dust control measures and elimination of asbestos at work.
dc.description.statementofresponsibilityMichael J Abramson, Tsitsi Murambadoro, Sheikh M Alif, Geza P Benke, Shyamali C Dharmage, Ian Glaspole, Peter Hopkins, Ryan F Hoy, Sonja Klebe, Yuben Moodley, Shuli Rawson, Paul N Reynolds, Rory Wolfe, Tamera J Corte, E Haydn Walters, For the Australian IPF Registry
dc.identifier.citationThorax, 2020; 75(10):864-869
dc.identifier.doi10.1136/thoraxjnl-2019-214478
dc.identifier.issn0040-6376
dc.identifier.issn1468-3296
dc.identifier.orcidReynolds, P.N. [0000-0002-2273-1774]
dc.identifier.urihttps://hdl.handle.net/2440/132687
dc.language.isoen
dc.publisherBMJ
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1106601
dc.rights© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions.
dc.source.urihttps://doi.org/10.1136/thoraxjnl-2019-214478
dc.subjectAustralian IPF Registry
dc.subjectHumans
dc.subjectOccupational Diseases
dc.subjectMetals
dc.subjectDust
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectEnvironmental Exposure
dc.subjectOccupational Exposure
dc.subjectAged
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.subjectIdiopathic Pulmonary Fibrosis
dc.subject.meshHumans
dc.subject.meshOccupational Diseases
dc.subject.meshMetals
dc.subject.meshDust
dc.subject.meshRisk Factors
dc.subject.meshCase-Control Studies
dc.subject.meshEnvironmental Exposure
dc.subject.meshOccupational Exposure
dc.subject.meshAged
dc.subject.meshAustralia
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshIdiopathic Pulmonary Fibrosis
dc.titleOccupational and environmental risk factors for idiopathic pulmonary fibrosis in Australia: case-control study
dc.typeJournal article
pubs.publication-statusPublished

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