Physiological functions of the HECT family of ubiquitin ligases

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dc.contributor.authorRotin, D.
dc.contributor.authorKumar, S.
dc.date.issued2009
dc.description.abstractThe ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 family members, are a major group of E3 enzymes that dictate the specificity of ubiquitylation. In addition to ubiquitylating proteins for degradation by the 26S proteasome, HECT E3 enzymes regulate the trafficking of many receptors, channels, transporters and viral proteins. The physiological functions of the yeast HECT E3 ligase Rsp5 are the best known, but the functions of HECT E3 enyzmes in metazoans are now becoming clearer from in vivo studies.
dc.description.statementofresponsibilityDaniela Rotin & Sharad Kumar
dc.identifier.citationNature Reviews Molecular Cell Biology, 2009; 10(6):398-409
dc.identifier.doi10.1038/nrm2690
dc.identifier.issn1471-0072
dc.identifier.issn1471-0080
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]
dc.identifier.urihttp://hdl.handle.net/2440/55019
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.grantARC
dc.source.urihttps://doi.org/10.1038/nrm2690
dc.subjectAnimals
dc.subjectHumans
dc.subjectUbiquitin-Protein Ligases
dc.subjectGuanine Nucleotide Exchange Factors
dc.subjectProtein Isoforms
dc.subjectUbiquitin
dc.subjectSignal Transduction
dc.subjectProtein Conformation
dc.subjectModels, Molecular
dc.subjectUbiquitination
dc.subjectEndosomal Sorting Complexes Required for Transport
dc.subjectNedd4 Ubiquitin Protein Ligases
dc.titlePhysiological functions of the HECT family of ubiquitin ligases
dc.typeJournal article
pubs.publication-statusPublished

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