Nitric oxide damage to colonocytes in colitis-by-association: Remote transfer of nitric oxide to the colon

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dc.contributor.authorRoediger, W.
dc.date.issued2002
dc.descriptionCopyright © 2002 S. Karger AG, Basel
dc.description.abstractNew observations of (1) colitis-by-association, (2) the carriage of nitric oxide by haemoglobin, (3) nitric oxide inactivation of CoA, (4) the damage caused to colonocytes by a combination of nitric oxide/sulphide/hydrogen peroxide and (5) colonic extraction of nitric oxide from the circulation, has led to new views on colonocyte damage in colitis. These observations should assist to define initiating factors that lead to release of damaging agents (nitric oxide/hydrogen peroxide) and to delineate protective mechanisms against colonocyte damage. Overall, the production, release, disposal and inactivation of nitric oxide are related to damage to colonocytes and consequent ulceration in colitis.
dc.description.statementofresponsibilityW.E.W. Roediger
dc.identifier.citationDigestion, 2002; 65(4):191-195
dc.identifier.doi10.1159/000063819
dc.identifier.issn0012-2823
dc.identifier.issn1421-9867
dc.identifier.orcidRoediger, W. [0000-0002-6480-4804]
dc.identifier.urihttp://hdl.handle.net/2440/10375
dc.language.isoen
dc.publisherKarger
dc.source.urihttps://doi.org/10.1159/000063819
dc.subjectNitric oxide
dc.subjectNitrite
dc.subjectColon
dc.subjectColitis
dc.subjectColonocyte
dc.subjectCoenzyme-A
dc.subjectSulphides
dc.titleNitric oxide damage to colonocytes in colitis-by-association: Remote transfer of nitric oxide to the colon
dc.typeJournal article
pubs.publication-statusPublished

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