Planned delivery or expectant management in pre-eclampsia: an individual participant data meta-analysis
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(Published version)
Date
2022
Authors
Beardmore-Gray, A.
Seed, P.T.
Fleminger, J.
Zwertbroek, E.
Bernardes, T.
Mol, B.W.
Battersby, C.
Koopmans, C.
Broekhuijsen, K.
Boers, K.
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American Journal of Obstetrics and Gynecology, 2022; 277(2):218-230
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Alice Beardmore-Gray, MBBS, Paul T. Seed, MSc, CStat, Jessica Fleminger, MEng, Eva Zwertbroek, MD, PhD, Thomas Bernardes, MD, PhD, Ben W. Mol, PhD, Cheryl Battersby, PhD, FRCPCH, Corine Koopmans, MD, PhD, Kim Broekhuijsen, MD, PhD, Kim Boers, MD, PhD, Michelle Y. Owens, MD, Jim Thornton, MD, Marcus Green, Andrew H. Shennan, MD, Henk Groen, PhD, Lucy C. Chappell, PhD
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Abstract
OBJECTIVE: Pregnancy hypertension is a leading cause of maternal and perinatal mortality and morbidity. Between 34þ0 and 36þ6 weeks gestation, it is uncertain whether planned delivery could reduce maternal complications without serious neonatal consequences. In this individual participant data meta-analysis, we aimed to compare planned delivery to expectant management, focusing specifically on women with preeclampsia. DATA SOURCES: We performed an electronic database search using a prespecified search strategy, including trials published between January 1, 2000 and December 18, 2021. We sought individual participant-level data from all eligible trials. STUDY ELIGIBILITY CRITERIA: We included women with singleton or multifetal pregnancies with preeclampsia from 34 weeks gestation onward. METHODS: The primary maternal outcome was a composite of maternal mortality or morbidity. The primary perinatal outcome was a composite of perinatal mortality or morbidity. We analyzed all the available data for each prespecified outcome on an intention-to-treat basis. For primary individual patient data analyses, we used a 1-stage fixed effects model. RESULTS: We included 1790 participants from 6 trials in our analysis. Planned delivery from 34 weeks gestation onward significantly reduced the risk of maternal morbidity (2.6% vs 4.4%; adjusted risk ratio, 0.59; 95% confidence interval, 0.36e0.98) compared with expectant management. The primary composite perinatal outcome was increased by planned delivery (20.9% vs 17.1%; adjusted risk ratio, 1.22; 95% confidence interval, 1.01e1.47), driven by short-term neonatal respiratory morbidity. However, infants in the expectant management group were more likely to be born small for gestational age (7.8% vs 10.6%; risk ratio, 0.74; 95% confidence interval, 0.55e0.99). CONCLUSION: Planned early delivery in women with late preterm preeclampsia provides clear maternal benefits and may reduce the risk of the infant being born small for gestational age, with a possible increase in short-term neonatal respiratory morbidity. The potential benefits and risks of prolonging a pregnancy complicated by preeclampsia should be discussed with women as part of a shared decision-making process.
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© 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).