Postnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasia

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dc.contributor.authorCummins, A.
dc.contributor.authorJones, B.
dc.contributor.authorThompson, F.
dc.date.issued2006
dc.description.abstractStudies of growth of the small intestine have largely concentrated on crypt hyperplasia rather than crypt fission. The aim of this study was to investigate quantitatively both crypt fission and crypt hyperplasia. DAxPVG/c rats were killed at 7, 11, 14, 17, 19, 21, 25, 55, and 72–73 days of life. Samples of jejunum at one third of the intestinal length were taken for morphometry (villous area, crypt area, percentage of bifid crypts, and crypt mitotic count) by microdissection. Growth factors and their receptors were assessed by oligonucleotide microarray. Crypt fission was 10.5%, 5.2%, and 1.5% at days 11, 25, and 72–73 of life, respectively. Crypt hyperplasia increased from day 21. No conventional growth factor was identified during crypt fission. We conclude that crypt fission contributes to growth of the small intestine prior to weaning and crypt hyperplasia to growth after weaning.
dc.description.statementofresponsibilityAdrian G. Cummins, Ben J. Jones, and Fiona M. Thompson
dc.identifier.citationDigestive Diseases and Sciences, 2006; 51(4):718-723
dc.identifier.doi10.1007/s10620-006-3197-9
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.orcidCummins, A. [0000-0003-3115-9498]
dc.identifier.urihttp://hdl.handle.net/2440/35696
dc.language.isoen
dc.publisherKluwer Academic/Plenum Publ
dc.source.urihttps://doi.org/10.1007/s10620-006-3197-9
dc.subjectcrypt fission
dc.subjectcrypt hyperplasia
dc.subjectgrowth of the small intestine
dc.subjectintestinal stem cells
dc.titlePostnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasia
dc.typeJournal article
pubs.publication-statusPublished

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