Porous silica microparticles from diatomaceous earth (De) for drug delivery applications
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(Published version)
Date
2010
Authors
Aw, M.S.
Simovic, S.
Yu, Y.
Addai Mensah, J.
Losic, D.
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Conference paper
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Chemeca 2010 proceedings: engineering at the edge, 2010, pp.1-10
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Engineering at the Edge (26 Sep 2010 - 29 Sep 2010 : Adelaide, Australia)
Abstract
Numerous mesoporous materials have been investigated in the last two decades to address therapeutic problems in drug delivery; for instance, poor bioavailability, low biodistribution, limited drug solubility, lack of selectivity and undesirable pharmacokinetics. In this work, a novel concept of using a silica-based natural mineral, refeiTed to as diatomaceous earth (DE), as a dmg caiTier is explored. DE is formed from algae, a type of unicellular phytoplankton, through its silica shells (fmstules) growth with ordered porous structures. To prove this concept we investigate loading and release of indomethacin, a poorly soluble drug from DE microparticles. The carrying capacity of DE was 22 wt % whereas indomethacin molecules in DE pores was released over a period of 12 days. This work demonstrates the application of DE microparticles as a drug carier for sustainable release of drugs.
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Copyright 2010 Engineers Australia